中文摘要：

促炎细胞因子在许多病理状态下,如炎症、神经系统损伤、癌症等,对疼痛和痛觉过敏的发生和维持有重要作用。目前得到普遍认可的促炎细胞因子有IL-1β、IL-6、TNF-α,该文就IL-1β在炎性疼痛中的作用及其可能的外周、中枢机制作一综述。

英文摘要：

Numerous studies have shown that pro-inflammatory cytokines induce or facilitate pain and hyperalgesia in the presence of inflammation,injury to the nervous system or cancer.At present,generally accepted pro-inflammatory cytokines are IL-1β,IL-6,TNF-α.This review outlines the recent findings of IL-1β in inflammatory pain and its possible peripheral and central mechanisms for the effects of IL-1β in nociceptive transmission.