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中文摘要：
动物季节性发情繁殖涉及下丘脑-垂体-性腺轴系统复杂的神经内分泌过程,并受光照周期等环境因素的影响。褪黑激素则作为光周期信号分子调控动物季节性繁殖活动。近年来研究发现,对GnRH分泌有重要影响的Kiss1/GPR54系统既受褪黑激素的调控又受到性腺类固醇激素反馈调节,Kiss1/GPR54系统很可能是调控动物季节性繁殖的关键因子;同时动物季节性繁殖很可能还存在一条涉及TSH-DIO2/DIO3系统的逆向调控通路,该系统同样显著影响GnRH合成释放并受褪黑激素调控。文章就褪黑激素中心信号,特别是Kiss1/GPR54和TSH-DIO2/DIO3系统对繁殖季节性调控的最新研究进展进行综述。
英文摘要：
Animal seasonal reproduction involves complicated neuroendocrine processes of the hypothalamo-pi-tuitary-gonadal axis.It is dominantly regulated by photoperiod,a crucial environmental cue.Melatonin,as internal photo-period signal,regulates seasonal reproduction of animals.In recent years,it has been found that Kiss1/GPR54 system,which may influence GnRH secretion evidently,is regulated by both melatonin and feedback action of gonadal steroid hormones.Consequently,Kiss1/GPR54 system may play a key role in seasonal reproduction.Additionally,there exists another potential retrograde control pathway of seasonal breeding,which involves TSH-DIO2/DIO3 system.TSH-DIO2/ DIO3 system affects synthesis and secretion of GnRH and is regulated by melatonin,as well as Kiss1/GPR54 system.In this article,melatonin signal,especially the research advances of Kiss1/GPR54 system and TSH-DIO2/DIO3 system were reviewed.
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