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Genomic organization and sequence analysis of the vomeronasal receptor V2R genes in mouse genome
  • ISSN号：1001-6538
  • 期刊名称：科学通报(英文版)
  • 时间：0
  • 页码：336-342
  • 语言：中文
  • 分类：Q754[生物学—分子生物学]
  • 作者机构：[1]Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China, [2]Graduate University of the Chinese Academy of Sciences, Beijing 100049, China, [3]Laboratory for Conservation and Utilization of Bio-resources, Yunnan University, Kunming 650091, China
  • 相关基金：Supported by National Natural Science Foundation of China （Grant Nos. 30430110 and 30021004）, and Yuunan Bureau of Science and Technology.The authors thank Wu DongDong for his effort in the chromosome map drawing.
  • 相关项目：分子进化与进化基因组学
作者： Yang, H.|Zhang, Y. P.|
关键词： 大白鼠, 基因组, 犁鼻受体2, 多基因超家族, 序列分析, mouse, vomeronasal receptor 2 （V2R）, gene family
中文摘要：

二多基因总科，命名 V1R 和 V2R， encodingseven-transmembrane-domain G 蛋白质联合了受体(GPCR ) 在哺乳动物作为 pheromonereceptors 被识别了。三个 V2R 基因家庭在老鼠和老鼠被描述了。这里，我们屏蔽了更新的鼠标染色体顺序数据库并且最后最新包括三检索了 63 通常认为的功能的 V2R 基因形成了一个新另外的家庭的识别基因。我们描述了这些基因的 thegenomic 组织并且也描绘了老鼠 V2R 蛋白质序列系统发生的保存。我们描述了的这些 genomic 和顺序信息作为证据 tos 的部分有用挪用 V2Rs 的功能的领域并且以后应该把帮助给功能学习。

英文摘要：

Two mulUgene superfamilies, named VIR and V2R, encoding seven-transmembrane-domain G-protein coupled receptors （GPCRs） have been identified as pheromone receptors in mammals. Three V2R gene families have been described in mouse and rat. Here we screened the updated mouse genome sequence database and finally retrieved 63 putative functional V2R genes including three newly identified genes which formed a new additional family. We described the genomic organization of these genes and also characterized the conservation of mouse V2R protein sequences. These genomic and sequence information we described are useful as pert of the evidence to speculate the functional domain of V2Rs and should give aid to the functionality study in the future.

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