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中文摘要：
充分利用基因组计划产生的大量信息以及我们的资源优势，不仅在分子水平研究生物多样性演变的格局和过程，并通过基因和基因组的深入分析，探讨生物适应进化的机制。强调一些重要的科学问题，比如人类早期迁移的路线和模式；自然选择（nature selcetion）,特别是正选择在基因进化和动物及人群适应进化中的作用；人工选择与动物家养化的机制等。揭示了人群在东亚的一些迁移历史，以及人类作出非洲后环境适应的一些遗传机制；证明了中国在动物家养化历史中的重要贡献，在家猪中发现了与早期驯化相关的基因；澄清了一些动物类群的演化历史与分化格局及其与地理历史环境的关系；对动物食性、运动能力、个体间通讯、体温保持等重要适应性状相关基因的研究，发现了动物适应进化的一些遗传机制。在影响因子大于9的国际著名刊物《Nature》(2)、 《Science》(2) 、《PNAS》(2)、《Genome Res》、《Am J Hum Genet》、 《Am J Respiratory Critical Care Med》发表或被接受论文9篇。
结论摘要：
英文主题词Molecular evolution; Molecular Systematics; Genome; Animals; Human Population
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期刊论文
Association of disease-predisposition polymorphisms of the melatonin receptors and sunshine duration
Development of 40 microsatellite markers in spotted halibut (Verasper variegatus) and the cross-spec
Lack of genetic association between the angiotensin-converting enzyme gene insertion/deletion polymo
A Profound Role for the Expansion of Trypsin-Like Serine Protease Family in the Evolution of Hematop
mtDNA Data Indicate a Single Origin for Dogs South of Yangtze River, Less Than 16,300 Years Ago, fro
Polymorphisms of the estrogen receptor alpha (ESR1) gene and the risk of Alzheimer's disease in a so
Genotyping of TRIM5 locus in northern pig-tailed macaques (Macaca leonina), a primate species suscep
Glucose and Lipid Profile of a Long-Lived Rural Han Chinese Population and Their Families in Southwe
Exploring factors shaping population genetic structure of the freshwater fish Sinocyclocheilus graha
Association of early growth response-1 gene polymorphisms with total IgE and atopy in asthmatic chil
Genome-wide computational identification of microRNAs and their targets in the deep-branching eukary
Absence of association between SERPINE2 genetic polymorphisms and chronic obstructive pulmonary dise
A paradigm for virus-host coevolution: Sequential counter-adaptations between endogenous and exogeno
Mitochondrial control region and population genetic patterns of Nycticebus bengalensis and N-Pygmaeu
Association of prostaglandin-endoperoxide synthase 2 gene polymorphisms with asthma and atopy in Chi
Paraphyly of Chinese Amolops (Anura, Ranidae) and phylogenetic position of the rare Chinese frog, Am
Phylogenetic relationships of the Chinese brown frogs (Genus rana) inferred from partial mitochondri
Analysis of complete mitochondrial genome sequences increases phylogenetic resolution of bears (Ursi
Li Y, Huang JF, Zhang YP. Adaptive Evolution of the First Extra Exon in the Murid Rodent Prolactin G
Gao JJ, Watabe HA, Aotsuka T, Pang JF, Zhang YP. Molecular phylogeny of the Drosophila obscura speci
Homologs of eukaryotic Ras superfamily proteins in prokaryotes and their novel phylogenetic correlat
Pleistocene isolation in the marginal ocean basins and limited dispersal in a marine fish, Chelon ha
Absence of association between SNPs in the promoter region of the insulin-like growth factor 1 (IGF-
Polymorphisms in the C-type lectin genes cluster in chromosome 19 and predisposition to severe acute
Strikingly different penetrance of LHON in two Chinese families with primary mutation G11778A is ind
Molecular phylogeny of Rhacophoridae (Anura): A framework of taxonomic reassignment of species withi
Xie HB, Irwin DM, Zhang YP. Evolution of conserved secondary structures and their function in transc
New Insights into the Evolution of Intronic Sequences of the beta-fibrinogen Gene and Their Applicat
Mitochondrial Cytochrome b Sequence Variations and Population Structure of Siberian Chipmunk (Tamias
Triosephosphate isomerase genes in two trophic modes of euglenoids (Euglenophyceae) and their phylog
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