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基因重复在基因选配（gene co-option）过程中的重要作用：对motilin／ghrelin荷尔蒙基因家族及其受体基因家族的进化研究
  • ISSN号：0023-074X
  • 期刊名称：《科学通报》
  • 时间：0
  • 分类：Q959.841[生物学—动物学]
  • 作者机构：[1]中国科学院昆明动物研究所遗传资源与进化国家重点实验室,昆明650223, [2]Departments of Laboratory Medicine and Pathobiology and the Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada, [3]云南大学生物资源保护与利用实验室,昆明650091
  • 相关基金：国家重点基础研究发展计划（2007CB411600）、国家自然科学基金（30621092,30623007）和云南省科技厅（0803481101）资助
作者： 何静[1], IrwinM.David, 张亚平[1,3]
关键词： GHRELIN, MOTILIN, 基因家族, 配体, 受体, 协同进化, 基因间相互作用
中文摘要：

原先存在的基因经过一些改良可能获得新的属性从而承担新的功能．在分子遗传的层次，这个过程通常伴随基因重复以及基因重复后旁系同源基因的功能分化．本研究探索了基因重复后荷尔蒙、受体间特异性相互作用的演化形成．尽管对这个问题已有相关研究报道，但针对更多个案的研究能帮助我们更好地理解此前已经提出的进化模型的普遍性，可能还有助于发现新的进化模式．基于生物信息学的手段，结合比较基因组学、系统发育学的方法，本研究揭示，ghrelin前体基因和motilin前体基因是由一个祖先基因重复而来，基因重复发生在羊膜动物与两栖动物刚刚分歧之后．与此形成鲜明对照，它们各自的特异性受体却呈现了很不一样的进化历史．GPR39最先分化出来，而后一个祖先基因经连续的基因重复分化为鱼类特异的进化支A，GHSR和MLNR，基因重复发生在射线鳍（ray—finnedfish）与四足动物分化之前．譬hrelin／GHSR信号系统的功能从鱼类到哺乳动物的进化过程中始终保守．motilin—MLNR之间的特异性相互作用是荷尔蒙基因重复后，MLN与GHRL基因分化之后，在羊膜动物世糸中配体与受体协同进化而形成的．该结果提示，在分子水平上，基于保守的分子元件，新的神经内分泌响应模式能够通过基因重复后的基因选配过程形成．基因重复既节俭又极具创造力，为生物多样性的演化提供了物质基础．

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期刊信息
  • 《科学通报》
  • 北大核心期刊（2011版）
  • 主管单位:中国科学院
  • 主办单位:中国科学院
  • 主编：周光召
  • 地址：北京东黄城根北街16号
  • 邮编：100717
  • 邮箱：csb@scichina.org
  • 电话：010-64036120 64012686
  • 国际标准刊号：ISSN：0023-074X
  • 国内统一刊号：ISSN：11-1784/N
  • 邮发代号:80-213
  • 获奖情况:
  • 首届国家期刊奖,中国期刊方阵“双高”期刊,第三届中国出版政府奖
  • 国内外数据库收录:
  • 美国化学文摘（网络版）,美国数学评论（网络版）,美国工程索引,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊（2004版）,中国北大核心期刊（2008版）,中国北大核心期刊（2011版）,中国北大核心期刊（2014版）,中国北大核心期刊（2000版）
  • 被引量:81792