采用火焰漂浮法制备新型含钇铁磁微晶玻璃微球(ferromagnetic glass ceramic microspheres,FGCMs),用以放疗与热疗相结合的医疗用途。通过热分析和X射线衍射(X-ray diffraction,XRD)研究热处理温度对FGCMs性能的影响。使用偏光显微镜观察FGCMs的形貌。用振动样品磁强计(vibrating sample magnetometer,VSM)和磁热测试装置研究FGCMs的磁性能和磁热性能。通过XRD和VSM数据计算样品中微晶相的含量。用比发热量和比能量吸收率表征FGCMs的发热能力。实验结果表明:FGCMs有很大的应用前景,可用于热疗-放疗联合治疗肿瘤。
Novel ferromagnetic glass ceramic microspheres(FGCMs) containing yttrium which can be used for clinical applications combining features of radiotherapy and hyperthermia were prepared by heat treatment and flame spray method.Influence of the heat treatment of ferromagnetic glass ceramic was investigated by the differential thermal analysis(DTA) and X-ray diffraction(XRD).Morphology of the FGCMs was characterized by the polarizing microscopy.Magnetism property and heating power of the FGCMs were measured by a vibrating sample magnetometry(VSM) and a thermomagnetic measurement equipment,respectively.Amount of crystallized magnetite was calculated by the XRD and VSM data.Specific heat values and specific absorption rate values of the FGCMs was calculated to characterize the heating ability of the FGCMs.The experimental results show that the FGCMs have great potential to offer the dual-function of hyperthermia and radiotherapy in the treatment of cancer.