中文摘要：

为探索具有荧光性能的锶羟基磷灰石作为骨疾病治疗用药物载体材料的应用前景，以Ca（NO3）2·4H2O）、sr（NO3）2、（NH4）2HP04、柠檬酸三钠、十六烷基三甲基溴化铵为原料，在180℃水热处理24h，制得了不同掺锶量的羟基磷灰石。表征了锶羟基磷灰石微球的晶相、形貌、组成、比表面积和荧光性能；研究了以锶羟基磷灰石作为载体，溶菌酶为模型药物的缓释效果。结果表明：合成的产物为花束状羟基磷灰石微球，随着掺锶量的增大，锶羟基磷灰石单球形貌由短棒状变为片状再变为长棒状，而比表面积和荧光强度则先增大后减小。此外，锶羟基磷灰石作为药物载体的缓释速率和释放量，随着锶含量的增大，呈现先减小后增大的趋势。

英文摘要：

In order to explore the potential application prospect of luminescent strontium-substituted hydroxyapatite as a drug carrier material in the field of bone disease treatment, hydroxyapatite powders with different mole ratios of Sr/（Ca＋Sr） were prepared by a hydrothermal method at 180 ℃ for 24h using Ca（NO3）2＂4H20）, Sr（NO3）2, （NHa）2HPO4, C6HsNaHOT＇2H20, cetyltrimethylammonium bromide （CTAB） as reagents. The crystalline phase, morphology, chemical composition, specific surface area and luminescent of the strontium-substituted hydroxyapatite were characterized, and the drug release properties of using the strontium-substituted hydroxya- patite as a drug carrier material and lysozyme as a model drug were investigated. The results show that the synthetic product was the bouquet-like hydroxyapatite microspheres, the unit morphology of the hydroxyapatite changed from short rod into sheet, and finally to a long rod, and the specific surface area and luminescence intensity both firstly increased and then decreased with increasing the amount of strontium doped. In addition, the amount and rate of release of strontium-substituted hydroxyapatite as a drug carrier firstly decreased and then increased with increasing the strontium-doped content.