中文摘要：

目的 研究基质金属蛋白酶（matrix metalloproteinase,MMP）2、MMP-9及组织金属蛋白酶抑制剂（tissue inhibitor of metalloproteinase,TIMP）1、TIMP-2在鼻腔鳞状细胞癌中的表达及意义.方法 应用免疫组化S-P法检测50例鼻腔鳞状细胞癌和50例中鼻甲或下鼻甲组织中MMP-2、MMP-9、TIMP-1和TIMP-2的表达,并分析它们的表达与临床病理结果间的关系.以SPSS 12.0软件对数据进行统计学分析.结果 鼻腔鳞状细胞癌组织和中鼻甲或下鼻甲组织中MMP-2阳性表达检出率分别为52.0%（26/50）、28.0%（14/50）,差异有统计学意义（x2=6.00,P＜0.05）;MMP-9阳性表达检出率分别为58.0%（29/50）、10.0%（5/50）,差异有统计学意义（x2=12.80,P＜0.05）;TIMP-1阳性表达检出率分别为74.0%（37/50）、56.0%（28/50）,差异无统计学意义（x2=0.51,P＞0.05）;TIMP-2阳性表达检出率分别为26.0%（13/50）、20.0%（10/50）,差异无统计学意义（x2=3.35,P＞0.05）.结论 鼻腔鳞状细胞癌的发生、发展与MMP-2、MMP-9表达有关系,MMP与TIMP比例失衡在判断鼻腔鳞状细胞癌侵袭性及预后中可能有一定意义.

英文摘要：

Objective To study the expression and significance of matrix metalloproteinase （MMP）2, MMP-9, tissue inhibitor of metalloproteinase （TIMP） 1 and TIMP-2 in nasal cavity squamous cell carcinoma and their signification. Methods Fifty cases of epithelial carcinoma tissue and 50 cases of normal nasal tissue were detected for MMP-2, MMP-9, TIMP-1, TIMP-2 by immunohistochemistry technique （S-P）, and their relationship between the expression of MMP-2, MMP-9, TIMP-1, TIMP-2 and some clinical symptoms were analyzed. The SPSS 12. 0 software was used to analyze the data. Results The positive ratio of expression of MMP-2 in 50 cases of epithelial carcinoma was 52. 0% （26/50）, which was significantly higher （ x2 = 6. 00, P ＜0. 05 ） than those [28.0% （14/50）] in the normal nasal tissue. The positive ratio of expression of MMP-9 in 50 cases of epithelial carcinoma was 58.0% （29/50）, which was significantly higher （ x2 = 12. 8, P ＜ 0. 05 ） than those [10. 0% （5/50）] in the normal nasal tissue. The positive ratio of expression of TIMP-1 in two groups was 74. 0% （37/50）, 56. 0% （28/50） respectively.There was no difference between two groups （ x2 = 0. 51, P ＞ 0. 05 ）. The positive ratio of expression of TIMP-2 in two groups was 26. 0% （ 13/50）, 20% （10/50） respectively. There was no difference between two groups（ x2 = 3.35, P ＞ 0. 05）. Conclusions There was a close relationship between pathogenesis and development of nasal epithelial carcinoma and the expression of MMP-2, MMP-9 in the epithelial carcinoma tissues. Both MMP and TIMP, especially the unbalance of MMP and TIMP, have prognostic value in nasal cavity squamous cell carcinoma.