中文摘要：

目的：旨在探讨大黄素干预大鼠动脉粥样硬化的作用及机制。方法：选择SPF级雄性SD大鼠48只,随机分为6组,每组8只,共饲养实验观察12周。普通饲料组全程每天给予普通饲料喂养,其它5组前8周每天给予高脂饲料喂养,后4周改为每天普通饲料喂养,并进行药物干预。大黄素大/中/小剂量3个组,分别给予大黄素80 mg/kg、40 mg/kg、20 mg/kg灌胃,阿托伐他汀组给予阿托伐他汀0.3 mg/kg灌胃,高脂饲料组和普通饲料组不给药物干预,仅给予等量（2 m L）生理盐水灌胃。6组在实验前和实验后第4、8、12周观察体质量的变化;第12周末处死动物,测其血清总抗氧化能力（total-antioxidant capacity,T-AOC）、超氧化物歧化酶（Superoxide Dismutase,SOD）、丙二醛（malonal dehyde,MDA）的含量;切片观察主动脉壁粥样硬化改变情况。结果：实验前各组大鼠间体质量的比较,差异无统计学意义（P〉0.05）。实验的第4周、8周、12周周末各组大鼠体质量均有增长,其中第4周末各组大鼠的体质量与实验前比较,差异均有统计学意义（P〈0.05）,各组间比较,差异无统计学意义（P〉0.05）;第8周末大黄素大/中/小剂量组、阿托伐他汀组、高脂饲料组的体质量显著高于普通饲料组（P〈0.05）;第12周末大黄素中/小剂量组、阿托伐他汀组、高脂饲料组的体质量显著高于普通饲料组（P〈0.05）。第12周末血清测定结果,大黄素大/中/小剂量组、阿托伐他汀组、高脂饲料组T-AOC、SOD的含量均高于普通饲料组,差异有统计学意义（P〈0.05）;而MDA的含量,高脂饲料组明显高于普通饲料组、大黄素大/中/小剂量组和阿托伐他汀组,差异有统计学意义（P〈0.05）。普通饲料组大鼠动脉壁形态正常,高脂饲料组呈明显的AS,中层平滑肌细胞增生,并向内膜下迁移,内膜水肿,并可见明显的泡沫状脂质颗粒沉积。大黄素大剂量组、阿托伐他汀组动?

英文摘要：

Objective： To investigate the role and mechanism of emodin on intervention of the formation of scleratheroma in rats artery. Methods： Forty-eight male SD rats in SPF were randomly divided into six groups, 8 rats in each group, all of which were observed based on the feeding experiments for 12 weeks. Normal diet group was given normal diet throughout the days. In the first 8 weeks, the other five groups were given high fat diet every day, and in the last 4 weeks were given normal diet and drug intervention. The three groups, emodin large/medium/small doses, were given emodin 80 mg/kg, 40 mg/kg, 20 mg/kg orally once a day. Atorvastatin group was given atorvastat 0.3 mg/kg orally once a day. High-fat diet group and normal diet group were not given drug intervention, and only given the same amount（2 mL） of normal saline once a day. In these six groups, changes of body mass were observed in the 4 th, 8 th, and 12 th week after the experiment. At the end of the 12 th week, the content of Total antioxidation（T-AOC）, malondialdehyde（MDA）, Superoxide dismutase（SOD） in serum were measured. Sliced observation of aorta atherosclerosis was also conducted. Result= The increase of body mass in the five high fat diet feeding groups was larger than that in normal diet feeding group （P 〈0.05）. The levels of T-AOC, SOD in emodin large/medium/low dose groups, atorvastadn group, the high-fat diet group were higher than those in normal diet group（P〈0.05）, while the content of MDA in high-fat diet group was significantly higher than that in the other five groups （P 〈 0.05）. High-fat diet group showed a significant slice of atherosclerosis. The artery wall of the normal diet group was in normal form, that of the emodin large dose and the atorvastatin group was close to the normal form. Conclusion： Emodin and atorvastatin may exert similar effect on rats atherosclerosis form.