中文摘要：

目的：探讨补肾抗骨松胶囊对激素性骨质疏松症（GIOP）的作用机制。方法：将60例GIOP患者，随机分为治疗组和对照组各30例。治疗组在原治疗的基础上加服补肾抗骨松胶囊治疗；对照组在原治疗基础上加服骨化三醇治疗。疗程均为90d。观察比较两组治疗前后血清骨保护素（OPG）、RANKL、骨碱性磷酸酶、尿I型胶原交联N端肽（NTx）水平和Ward§三角区骨密度指标变化。结果：治疗后两组血清OPG、RANKL、骨碱性磷酸酶、NTx、Ward＇s三角区骨密度与治疗前比较，均明显改善，差异有统计学意义（P〈0．05）；治疗组改善程度优于对照组（P〈0．05）。结论：补肾抗骨松胶囊治疗GIOP具有一定优势，优于骨化三醇的“替代疗法”，推测其机制，可能是通过OPG—RANKL—RANK骨调节轴促进骨质的形成与吸收。

英文摘要：

Objective ：To investigate the action mechanism of kidney -tonifying and anti -osteoporosis capsules in the treatment of glucocorticoid -induced osteoporosis （GIOP）. Methods：Sixty patients with GIOP were randomly divided into treatment group （n = 30 ）and control group （n = 30）. The treatment group was given kidney -tonifying and anti -osteoporosis capsules in addition to conventional treatment, while the control group was given calcitriol in addition to conventional treatment. The course of treatment was 90 d in both groups. Serum levels of osteoprotegerin （ OPG）, receptor activator of nuclear factor kappa - B ligand （ RANKL）, bone alkaline phosphatase （ BAP）, and u- rinary cross- linked N- telopeptide of type I collagen （NTx）and Ward~ triangle bone mineral density were meas- ured before and after treatment. Results：After treatment, both groups showed significant improvements in serum lev- els of OPG, RANKL, BAP, and NTx and Ward~ triangle bone mineral density （P 〈 0. 05 ） ;the treatment group had significantly more improvements than the control group （ P 〈 0. 05 ）. Conclusion ： Kidney - tonifying and anti - osteo- porosis capsules have advantages in treating GIOP and are superior to the substitutive therapy with calcitriol. They may promote the formation and absorption of bone by the OPG - RANKL - RANK system.