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中文摘要：
目的：观察双参宁心方对大鼠心肌缺血损伤模型血清EPO水平的变化及心肌保护作用的影响。方法：冠状动脉结扎法建立大鼠心肌缺血模型,术后缝合伤口继续喂养。按假手术组、模型组、双参宁心180 mg/kg组、双参宁心90 mg/kg组、双参宁心45 mg/kg组,分别给予生理盐水及双参宁心水溶液5日。末次给药后0.5h采血,摘取心脏。ELISA检测血清中EPO含量。N-BT染色法计算心肌梗死范围,生化仪测血清中乳酸脱氢酶（LDH）漏出率。结果：模型组心肌梗死面积明显异常,血清中LDH漏出率增高,EPO含量降低,与假手术组比较均差异显著。双参宁心处理后心肌梗死面积缩小,血清中LDH含量降低,EPO含量增加,与模型组比较均差异显著。结论：大鼠心肌缺血损伤5日后,EPO水平降低。双参宁心可能通过促进EPO的分泌而保护受损心肌,表现为心肌梗死面积减小,血清中LDH漏出率降低。
英文摘要：
Objective： To investigate the effects of SSNX on erythropoietin（EPO） during myocardial ischemia injury.Method： Model rat of myocardial ischemia injury was established by coronary arterial ligating.Anterior descending branch of coronary artery was ligated.ELISA were applied to detection of EPO contents.Result： The expression of EPO treated with 双参宁心 was significantly increased compare to model group.Conclusion： Cardioprotective effects of SSNX possibly relate to increased the expression of EPO during myocardial ischemia injury.
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