中文摘要：

目的对与2型糖尿病（T2DM）患者肝脏甘油三酯含量（HTC）相关的因素进行分析,比较T2DM合并和不合并非酒精性脂肪性肝病（NAFLD）患者的临床特征之间的差异。方法入选55例T2DM患者,进行人体学特征和血清生化指标检测,同时行肝脏磁共振氢谱（1H-MRS）检查测定HTC。然后根据HTC结果将患者分成合并和不合并NAFLD两组,比较两组患者临床特征之间的差异。结果T2DM患者HTC与体重指数（BMI）、腰围、腰臀比（WHR）、舒张压（DBP）、血清谷丙转氨酶（ALT）、谷草转氨酶（AST）、空腹胰岛素（FINS）、甘油三酯（TG）呈正相关（P〈0.05或P〈0.01）,合并NAFLD的T2DM患者腹型肥胖更明显,ALT和TG水平更高。结论T2DM患者肝脏甘油三酯含量与代谢指标密切相关,合并NAFLD的T2DM患者呈现更显著的代谢异常。

英文摘要：

Objective To analyze factors which are correlated with hepatic triglyceride contents（HTCs）in type 2 diabetic （T2DM）patients and investigate the differences in clinical features between diabetic patients with or without non-alcoholic fatty liver disease（NAFLD）. Methods Fifty-five type 2 diabetic patients were selected. Anthropometric features and serum biochemical markers were tested. HTCs were quantified by proton magnetic resonance spectroscopy（^1H-MRS）scan of the liver. Then subjects were divided into two groups（with or without NAFLD）according to the result of HTCs. Clinical characteristics between two groups were compared. Results Body mass index（BMI） ,waist circumference,waist-hip ratio（WHR） ,diastolic blood pressure（DBP）, plasma alanine aminotransferase（ALT） ,aspartate aminotransferase（ AST）, fasting insulin（ FINS）, and triglyc eride（TG）in diabetic patients were significantly correlated with HTCs. It was also found that diabetic patients with NAFLD were more abdominally obese and their plasma concentrations of ALT and lipid were higher than in their counterparts without NAFLD. Conclusion Fat accumulation in the liver is associated with characteristics of metabolic syndrome. Significant metabolic abnormalities existed in type 2 diabetic patients with NAFLD.