中文摘要：

目的探讨黄连与肉桂不同配伍比例对交泰丸中小檗碱溶出率的影响。方法各组中药采取水煎法，小檗碱检测条件：色谱柱XTerraP18（4．6mm×250mm，5μm）；流动相：0．05mol·L-1磷酸二氢钾（用磷酸调pH至3．5）-乙腈（70：30）；检测波长：346nm；柱温：40℃；流速0．9mL·min-1；进样量：10μL。结果黄连：肉桂=1：0．25，1：0．5与黄连单煎荆小檗碱提取率差异明显，且随肉桂比例提高，小檗碱煎出率降低。结论肉桂对黄连有效成分小檗碱的溶出具一定的抑制作用。

英文摘要：

Objective To explore the effects of cinnamon and coptis in different compatibility proportion on the dissolu- tion rate of berberine from fiaotai bolus. Methods All the drugs were decocted and berberine content was determined on HPLC with a UV detector based on the following parameters： XTerra P18 （4.6 mm×250 mm, 5 μm） column, acetonitrile- 0.05 mmol · L-1 potassium dihydrogenphosphate （30 ： 70, pH 3.5 adjusted by phosphoric acid） as mobile phase, detection wavelength 346 nm, column temperature 40 ℃, flow rate 0.9 mL · min-1 and loading sample volume 10 μL. Results There was marked difference in the extraction ratio of berberine between cinnamon combined with coptis in the proportion of 1 ： 0.25, 1 ： 0.5, and coptis single decoction. Moreover, the decoction rate of berberine decreased with cinnamon proportion increasing. Conclusion Cinnamon has inhibitory effect on dissolution of berberine from coptis.