中文摘要：

目的：探讨中国汉族人群一氧化氮合酶1接头蛋白（NOS1AP）基因rs348624多态性与早发性精神分裂症的易感性及其首发年龄的关联性。方法：选取285例早发性精神分裂症患者为研究组和826名正常对照组,采用Taq Man法,检测NOS1AP基因rs348624位点多态性,并分析研究组危险等位基因的频率与首发年龄的关联性。结果：研究组与对照组rs348624等位基因和基因型频率分布比较差异有统计学意义[χ2=149.17,自由度（df）=1,P=0.00;χ2=137.25,自由度（df）=2,P=0.00];Kaplan-Meier分析显示,rs348624等位基因T的频率与早发性精神分裂症首发年龄显著相关（Kaplan-Meier log rank检验P=0.00）。结论：在中国汉族人群中NOS1AP基因与早发性精神分裂症存在关联,其rs348624多态性可能是导致早发性精神分裂症患者发病年龄提前的重要因素。

英文摘要：

Objective： To investigate the association between the Nitric oxide synthase 1 adaptor protein （NOS1AP） gene polymorphisms with early-onset schizophrenia in the Han Chinese population. Method： NOS1AP tag single nucleotide polymorphisms （tag SNPs） rs348624 were genotyped using TaqMan SNP genoty- ping assay in 285 early-onset schizophrenia patients and 826 healthy controls. The allele and genotype frequen- cies were performed and the association with age at onset was evaluated. Results： There were significant difference in allele and genotype frequencies between patients and control subjects for rs348624（X2 = 149.17, dr= 1, P = 0.00 ;X2 = 137.25, dr= 2 ,P = 0.00）. The T allele was significantly associated with an earlier age of onset in early-onset schizophrenia patients（ Kaplan-Meier log rank test P = 0. 00）. Conclusion ：The NOSI AP gene rs348624 polymorphisms may play important roles in the susceptibility and onset age to early-onset schizo- phrenia in the Han Chinese population.