目的观察润肺健脾补肾方治疗慢性阻塞性肺疾病稳定期重度、极重度肺燥阴伤、脾肾气虚兼痰瘀证患者的中医证候积分和6 min步行距离(6 MWT)的影响。方法将79例患者随机分为治疗组39例和对照组40例。对照组吸入舒利迭治疗,每日2次。治疗组在对照组基础上,加润肺健脾补肾方口服,两组疗程均为3个月。疗程结束后统计并比较两组中医证候积分和6 MWT变化情况。结果两组中医证候积分与治疗前比较差异有统计学意义,两组治疗后比较除喘息外差异有统计学意义,两组中医证候总积分疗后比较差异有统计学意义,两组6 MWT与治疗前比较,差异有统计学意义,治疗后比较,差异也有统计学意义(以上P〈0.01或P〈0.05)。结论润肺健脾补肾方治疗慢性阻塞性肺疾病稳定期重度、极重度肺燥阴伤、脾肾气虚证患者有较好的治疗效果,临床应用安全。
Objective:To observe the effect of Runfeijianpibushen Decoction on scores of traditional Chinese medicine(TCM) and 6 MWT of patients with chronic obstructive pulmonary disease(COPD) in stationary phage(severe to profound lung dryness and spleen-kidney deficiency plus phlegm stagnation).Methods:79 patients were randomly divided into two group:control group(n = 40) were given inhaled Seretide(2 times per day),and treatment group(n = 39) were given Runfeijianpibushen Decoction besides inhaled Seretide.The courses of treatment for both groups were 3 months.Then scores of TCM and 6MWT were compared between these two groups.Results:There were statistically significant differences in scores of TCM between pre-and post-treatment in both groups.After treatment,except for wheeze,all symptoms,scores of TCM,and 6MWT were statistically significant between two groups(P0.01 or P0.01).Conclusion:Runfeijianpibushen Decoction is effective and safe in treating patients with COPD in stationary phage(severe to profound lung dryness and spleen-kidney deficiency plus phlegm stagnation).