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中文摘要：
通过卵巢交互移植，构建实验小鼠的瘦素长受体（LR）基因型组合分别为A（躯体LR＋，卵巢LR-）、B（躯体LR＋，卵巢LR＋）、C（躯体LR-，卵巢LR＋）、D（躯体LR-，卵巢LR-）共4组（A组n=10、余皆n=5）。与A、B组比较，C、D组糖脂代谢水平及卵巢功能各项指标之间均存在显著差异。证实卵巢内存在完整的瘦素信号转导系统；卵巢局部瘦素信号转导缺失并不影响卵巢自身的生殖功能。
英文摘要：
Four genotypic mice were constructed, by ovary transplantation, with body leptin receptor （LR） ＋ and ovaryLR- in Group A, body LR＋ and ovary LR＋ in Group B, body LR- and ovary LR＋ in Group C, as well as body LR - and ovary LR - in Group D respectively. Mice in C and D groups showed significant differences in glucose and fat metabolism as well as ovarian function as compared with A and B groups. Leptin signal transducting system exists in the ovary. Ovarian failure was induced by hyperlipidemia and lowered gonadotropin levels, but not by defective leptin signal within ovaries in the db/db mice.
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