东篱科研大数据发现系统（DRDS）

位置：成果数据库 > 期刊 > 期刊详情页

Synchrotron radiation X-ray fluorescence analysis of Fe, Zn and Cu in mice brain associated with Parkinson＇s disease

ISSN号：0023-074X
期刊名称：《科学通报》
时间：0
分类：Q426[生物学—神经生物学;生物学—生理学] TQ174.66[化学工程—陶瓷工业;化学工程—硅酸盐工业]
作者机构：[1]KeyLaboratoryofInterfacialPhysicsandTechnology,ChineseAcademyofSciences,Shanghai201800,China, [2]ShanghaiInstituteofAppliedPhysics,ChineseAcademyofSciences,Shanghai201800,China, [3]UniversityofChineseAcademyofSciences,Beijing100049,China, [4]UCBPharm,SloughSL13WE,UK
相关基金：Supported by the Ministry of Science and Technology of China（Nos.2012CB825805 and 2012CB932600）; National Natural Science Foundation of China（Nos.11179004,21390414,U1232113,U1232114,U1332119 and U1432116）; Youth Innovation Promotion Association of CASACKNOWLEDGMENTS ACKNOWLEDGMENTS We are grateful to Prof. YU Xiao-Han and his colleagues at beamline BL15U in SSRF for their support with beamline operation and data collection.

作者：田甜[1,2,3], 张继超[1,2], 雷豪志[1,2], 诸颖[1,2], 施继晔[4], 胡钧[1,2], 黄庆[1,2], 樊春海[1,2], 孙艳红[1,2]

关键词：同步辐射X射线荧光分析, 帕金森病, 锌含量, 鼠脑, 低铁, 神经退行性疾病, 小鼠模型, Fe含量, Synchrotron radiation X-ray fluorescence,Metal element,Trace and analysis,Rapamycin,Parkinson＇s diseases

中文摘要：

The contents and distributions of metal elements in the brain are closely related to neurodegenerative diseases.In this study, we examined Fe, Cu and Zn contents in the brain section associated with Parkinson‘s disease(PD)using synchrotron radiation X-ray fluorescence(SRXRF). PD mouse model induced by 1-methyl-4-phenyl-1,2,3,6-terahydropyridine(MPTP) was used for the elemental analysis(e.g., Fe, Cu and Zn) in the substantia nigra pars compacta(SNpc) region of mice brain tissue samples. We found that mice in the MPTP group had higher contents of Fe, Cu and Zn in the SNpc than the control group. After treating the PD mice with rapamycin, the contents of Fe, Cu and Zn were reduced, the dopamine neurons and motor function were rescued correspondingly. The results prompted that the SRXRF provided an ideal method for tracing and analyzing the metal elements in the brain section to assess the pathological changes of PD model and the therapeutic effect of drugs.

英文摘要：

The contents and distributions of metal elements in the brain are closely related to neurodegenerative diseases.In this study, we examined Fe, Cu and Zn contents in the brain section associated with Parkinson‘s disease（PD）using synchrotron radiation X-ray fluorescence（SRXRF）. PD mouse model induced by 1-methyl-4-phenyl-1,2,3,6-terahydropyridine（MPTP） was used for the elemental analysis（e.g., Fe, Cu and Zn） in the substantia nigra pars compacta（SNpc） region of mice brain tissue samples. We found that mice in the MPTP group had higher contents of Fe, Cu and Zn in the SNpc than the control group. After treating the PD mice with rapamycin, the contents of Fe, Cu and Zn were reduced, the dopamine neurons and motor function were rescued correspondingly. The results prompted that the SRXRF provided an ideal method for tracing and analyzing the metal elements in the brain section to assess the pathological changes of PD model and the therapeutic effect of drugs.

同期刊论文项目