中文摘要：

目的 探讨血清趋化素（Chemerin）水平与MS的相关性. 方法 选取非MS（Non-MS）组57例,MS组117例及健康对照（NC）组90名,按Chemerin水平从低到高分为Ter1、Ter2和Ter3亚组.所有研究对象行75 g OGTT和胰岛素释放试验,检测血脂、血清Chemerin、高敏C反应蛋白（hsC-RP）等相关生化指标. 结果 MS组血清Chemerin水平高于Non-MS组和NC组（P＜0.01）.从Ter1到Ter3亚组,BMI、WC、WHR、SBP、FPG、2 hPG、HbA1 c、FIns、HOMA-IR、TG、hsC-RP水平依次升高,HDL-C水平依次降低,MS的患病率依次增加（P＜0.05）.Chemerin与BMI、WC、WHR、SBP、FPG、2 hPG、HbA1 c、FIns、2 hIns、HOMA-IR、TG及hsC-RP呈正相关（P＜0.05）,与HDL-C、胰岛β细胞功能指数（HOMA-β）呈负相关（P＜0.01）.Logistic逐步回归分析显示,Chemerin是MS的独立危险因素（OR=2.197,P＜0.01）.受试者工作曲线（ROC）曲线提示Chemerin预测MS的界值为72.4 ng/ml.结论 Chemerin与MS的发生相关,可作为MS的独立预测指标之一.

英文摘要：

Objective To investigate the relationship between the levels of serum chemerin and metabolic syndrome（MS）.Methods 264 subjects were divided into MS group（n=117）,non-MS group （n=57）,and normal controls（NC） group（n=90）.All the subjects were divided into three subgroups：Ter1,Ter2 and Ter3 according to the levels of serum chemerin.A 75 g OGTT and insulin releasing test were performed.Mean-while,blood lipid,serum chemerin,hsC-RP and other items were measured.Results The serum chemerin was higher in MS group than in non-MS group and NC group.The level of BMI,WC,WHR,SBP,FPG,2 hPG,HbA1 c,FIns,HOMA-IR,TG was in turn increased from Ter1 to Ter3 Subgroup,the level of hsC-RP and the prevalence of MS were in turn increased,while HDL-C was decreased（P〈0.05）.Chemerin was positively correlated with BMI,WC,WHR,SBP,FPG,2 hPG,HbA1 c,FIns,2 hIns,HOMA-IR,TG and hsC-RP （P 〈 0.05）,and negatively correlated with HDL-C,HOMA-β（P〈0.01）.Logistic regression analysis showed serum chemerin was positively associated with MS（OR=2.197,P〈0.01）.The area under ROC curve suggested that MS-predicting chemerin cut-off point was serum chemerin 72.4 ng/ml.Conclusion Serum chemerin is associated with the occurrence of MS and might be an independent predictor for MS.