中文摘要：

目的：观察肥胖及2型糖尿病患者体内血清催产素及超敏 C 反应蛋白（hs-CRP）水平,探讨催产素与 hs-CRP、糖脂代谢、胰岛素抵抗及胰岛β细胞功能的关系。方法选取研究对象176例,其中新诊断2型糖尿病（T2DM）患者88例、正常糖耐量（NGT）个体88例,以体重指数25 kg/ m2为切点将研究对象分为正常体重（NW）亚组和肥胖（OB）亚组。所有研究对象均行口服75 g 葡萄糖耐量试验（OGTT）,检测HbA1C、空腹血糖、餐后2 h 血糖、空腹胰岛素、餐后2h 胰岛素及血脂水平,并以稳态模型评估的胰岛素抵抗指数（HOMA-IR）及胰岛β细胞功能（HOMA-β）。采用化学发光法检测 hs-CRP 水平,采用酶免法检测血清催产素水平。结果 T2DM 组血清催产素水平显著低于 NGT 组（P〈0.01）,T2DM 组血清 hs-CRP 水平显著高于 NGT 组（P〈0.01）。在 T2DM 组和 NGT 组内,OB 亚组催产素水平均低于对应的 NW 亚组[7.16（6.45~8.82）对7.98（7.03~9.17） ng/ L；9.23（8.16~10.36）对9.86（8.77~12.06） ng/ L, P〈0.05]；OB亚组 hs-CRP 水平均高于对应的 NW 亚组[0.99（0.25~1.97）对0.54（0.19~0.91） mg/ L；3.47（1.63~6.20）对1.65（0.81~3.81） mg/ L, P〈0.05]。相关性分析显示血清催产素与 hs-CRP、体重指数、腰围、腰臀比、HbA1C、空腹血糖、餐后2 h 血糖、空腹胰岛素、餐后2 h 胰岛素、总胆固醇、甘油三酯、LDL-C、HOMA-IR呈负相关（P〈0.05或 P〈0.01）,与 HOMA-β呈显著正相关（P〈0.01）。根据 hs-CRP 水平将研究对象按三分位分组,随着 hs-CRP 水平升高,催产素水平显著降低（P〈0.05或 P〈0.01）。结论血清催产素水平在肥胖及2型糖尿病患者体内降低,其与炎症程度、体重指数、糖脂代谢紊乱、胰岛素抵抗及胰岛β细胞功能密切相关,提示催产素可能参与肥胖和2型糖尿病的发生发展。

英文摘要：

Objective To detect serum oxytocin and highly sensitive C-reactive protein （hs-CRP） levels in obese and type 2 diabetes mellitus（T2DM） subjects and investigate the relationships between serum oxytocin levels and hs-CRP, glycolipid metabolism, insulin resistance and pancreas β cell function. Methods A total of 176 subjects were enrolled in the study, including 88 patients with newly-diagnosed type 2 diabetes （ T2DM） and 88 subjects with normal glucose tolerance（NGT）. NGT and T2DM groups were further divided each into normal weight （NW） and obese（OB） subgroups. Obesity was defined as body mass index（BMI）≥25 kg/ m2 according to the WHO-Western Pacific Region diagnostic criteria （2000）. 75g oral glucose tolerance test （ OGTT） was performed in all subjects. Fasting plasma glucose （ FPG）, 2 h postprandial plasma glucose （2hPG）, fasting insulin （ FINS）, 2h postprandial serum insulin（2hINS）, HbA1C and lipids were also determined. Insulin resistance and pancreas β-cell function were determined by homeostasis model assessment （ HOMA-IR, HOMA-β）. Highly sensitive C-reactive protein（hs-CRP） level was determined by chemiluminescence immunoassay and fasting serum oxytocin level was determined by ELISA. Results Serum oxytocin level was lower in T2DM group than that in NGT group（P〈0. 01）, while serum hs-CRP level was higher in T2DM group than that in NGT group（P〈0. 01）. The level of serum oxytocin in subjects with obesity was also lower than that in subjects with NW in both NGT and T2DM groups [7. 16（6. 45-8. 82）＆nbsp;vs 7. 98（7. 03-9. 17） ng/ L and 9. 23（8. 16-10. 36） vs 9. 86（8. 77-12. 06） ng/ L, P〈0. 05]. The level of serum hs-CRP in subjects with obesity was higher than that in subjects with NW in both NGT and T2DM groups [0. 99（0. 25-1. 97） vs 0. 54（0. 19-0. 91） mg/ L and 3. 47（1. 63-6. 20） vs 1. 65（0. 81-3. 81） mg/ L, P〈0. 05]. Serum oxytocin level was negatively correlated with hs-CRP, BMI, WC, WHR, HbA1C , F