中文摘要：

目的探讨24h眼压监测在青光眼患者个体化用药指导中的作用。方法对36例（57眼）原发性开角型青光眼,2例（3眼）正常眼压性青光眼患者行24h眼压监测,根据其眼压峰值,结合临床所用药物药效峰值时点,个体化指导用药,在出院后1个月复测24h眼压,3、6个月后再次测眼压,并随访视力、视野。结果入选患者在出院后3、6个月,眼压峰值、眼压谷值、眼压波动值、眼压均值均低于个体化用药前,差异有统计学意义（P〈0.05）,出院后3个月,34眼（56.7%）基线眼压峰值下降大于30%,26眼（43.3%）基线眼压峰值下降20%-30%;出院后6个月,41眼（68.3%）基线眼压峰值下降大于30%,19眼（31.7%）基线眼压峰值下降20%-30%。结论以患者24h眼压规律来个体化指导青光眼患者临床用药,具有个体针对性,能提高药物治疗的有效性,利于控制眼压,保护患者视功能,是一种值得推广的用药指导模式。

英文摘要：

Objective To investigate the role of 24 h intraocular pressure（IOP） monitoring in the personalized medication guidance of glaucoma patients .Methods 24 h IOP was performed in 36 cases （57 eyes） of primary open‐angle glaucoma and 2 cases （3 eyes） of normal tension glaucoma ,the personalized medication guidance was given ac‐cording to the IOP peak and combining with the drug efficacy peak point ,then 24 h IOP was re‐checked in 1 ,3 ,6 months after discharging from hospital ,the visual acuity and the field of vision were followed up .Results The peak IOP ,mean IOP ,IOP valley and IOP fluctuation in 3 ,6 months after discharge from hospital in the enrolled personal‐ized medicated patients were obviously lower than those before the personalized mediction ,the differences werestatis‐tically significant （P〈0 .05）;in 3 months after discharge from hospital ,the baseline of peak IOP in 34 eyes （56 .7% ） was decreased by more than 30% ,which in 26 eyes （43 .3% ） was decreased by 20% -30% ;in 6 month after dis‐charge ,the baseline of peak IOP in 41 eyes（68 .3% ） was declined by more than 30% and which in 19 eyes （31 .7% ） was declined by 20% -30% .Conclusion Guiding the personalized clinical medication of glaucoma patients according to 24 h IOP rule possesses the personalized pertinence ,can increase the medication effectiveness ,conduces to control IOP protect patient′s visual function and is a kind of medication guidance mode deserving to be popularized .