中文摘要：

目的 ：探讨微RNA-146a（microRNA-146a,miRNA-146a）基因rs2910164位点多态性与胃癌易感性的关系。方法 ：计算机检索PubMed、EMBASE、Cochrane Library、中国期刊全文数据库、中国生物医学文献数据库、维普数据库和万方数据库,收集关于miRNA-146a rs2910164多态性与胃癌罹患风险关系的病例-对照研究。根据文献纳入及排除标准筛选研究文献,提取数据并进行质量评价。采用STATA 12.1软件进行Meta分析,计算合并比值比（odds ratio,OR）及95%可信区间（coni dence interval,CI）,并进行亚组分析、敏感性分析和发表偏倚检测。结果 ：共纳入8个病例-对照研究,包括胃癌患者4 308例,非肿瘤对照者6 320例。Meta分析结果显示,miRNA-146a rs2910164多态性与胃癌罹患风险无统计学相关性（C vs G：OR=0.95,95%CI：0.84～1.08;GG＋CG vs CC：OR=1.05,95%CI：0.85～1.29;GG vs CC＋CG：OR=1.12,95%CI：0.94～1.34;CC vs GG：OR=0.91,95%CI：0.71～1.16;CG vs GG＋CC：OR=0.95,95%CI：0.88～1.03）。敏感性分析时剔除了异质性较大的一篇研究（Okubo等）后,C vs G及CC vs GG模型基因多态性与胃癌易感性相关,差异有统计学意义（OR=0.87,95%CI：0.84～0.95;OR=0.80,95%CI：0.70～0.91）。根据Lauren’s分型的亚组分析显示,GG vs CC＋CG模型基因多态性与肠型胃癌的罹患风险增高相关（OR=1.24,95%CI：1.04～1.48）。结论 ：miRNA-146a基因rs2910164位点多态性可能与胃癌易感性无相关性。

英文摘要：

Objective： To explore the association between a single nucleotide polymorphism （SNP） in rs2910164 of microRNA-146a （miRNA-146a） gene and the susceptibility to gastric cancer （GC）. Methods： A computer-based online search was performed by using PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure, Chinese Biomedical Literature Data, VlP Database and Wanfang Database. The case-control studies associated between miRNA-146a rs2910164 polymorphism and the susceptibility of GC were selected according to the inclusion and exclusion criteria. After data extraction and quality evaluation, a Meta-analysis was performed by using STATA 12.1 software. Odds ratio （OR） and its 95% confidence interval （CI） were calculated. Then the subgroup analysis, sensitivity analysis and publication bias test were performed. Results： A total of 8 case-control studies were included in this Meta-analysis, including 4 308 cases and 6 320 non-tumor controls. Meta-analysis showed that the miRNA-146a rs2910164 polymorphism was not significantly associated with the risk of GC in an allele model （C vs G） （OR = 0.95, 95% CI： 0.84-1.08）, additive model （CC vs GG） （OR = 0.91, 95% CI： 0.71-1.16）, dominant model （GG ＋ CG vs CC） （OR = 1.05, 95% C/： 0.85-1.29）, recessive model （GG vs CC ＋ CG） （OR = 1.12, 95% CI： 0.94-1.34） and codominant model （CG vs GG ＋ CC） （OR = 0.95, 95% CI： 0.88-1.03）. Sensitivity analysis which excluded a study （from Okubo M, et al） showed that allele model and additive model were significantly associated with the risk of GC （OR = 0.87, 95% CI： 0.84-0.95; OR = 0.80, 95% CI： 0.70-0.91）.Subgroup analysis by Lauren＇s type revealed that the recessive model （GG vs CC ＋ CG） was associatedwith the increased risk of GC （OR = 1.24, 95% CI： 1.04-1.48）. Conclusion： miRNA-146a rs2910164 polymorphism may be not significantly associated with the GC susceptibility.