中文摘要：

目的 定量评价进展期胃癌患者中谷胱甘肽S转移酶pi（GSTP1）基因105氨基酸位点Ile/Val多态性与铂类药物化疗敏感性的关系.方法 检索中国期刊全文数据库（CNKI）、中文科技期刊全文数据库（VIP）、中国生物医学文献数据库（CBM）、万方数据库、PubMed、EMBASE、Cochrane Library,收集国内外公开发表的关于GSTP1 Ilel05Val基因多态性与胃癌铂类药物化疗敏感性关系的文献.临床有效（完全缓解＋部分缓解）作为评价化疗敏感性的指标.运用RevMan 5.2进行Meta分析,计算合并比值比（OR）及95％可信区间（CI）,运用Stata 12.0识别是否存在发表偏倚.结果 本研究纳入6项研究共计病例724例,Meta分析结果显示,各基因型间（GG＋GAvs AA：OR=2.38,95％ CI为1.29～4.38;GG vs GA＋ AA：OR=3.66,95％ CI为1.18 ～ 11.39;GG vs AA：OR=4.42,95％ CI为1.28～15.26）以及亚洲人群亚组（GG＋ GA vs AA：OR=2.93,95％CI为1.33 ～ 6.48）中GSTP1 Ilel05Val多态性与化疗敏感性的差异有统计学意义.结论 GSTP1 Ile105VaI（A/G）基因多态性可能与进展期胃癌铂类化疗药物敏感性相关.

英文摘要：

Objective To quantitatively evaluate the association between Ilel05Val polymorphism of glutathione S-transferase pi （GSTP1） and sensitivity to platinum-based chemotherapy in advanced gastric canc- er. Methods The relevant published literatures about Ilel05Val polymorphism of GSTP1 and sensitivity to platinum-based chemotherapy in gastric cancer were retrieved from China National Knowledge Internet （CNKI） , VIP, Chinese Biomedical Literature Data （CBM）, Wan-Fang databases, PubMed, EMBASE and Coehrane Library. Clinical response （complete response and partial response） was employed to estimate chemo- sensitivity. Meta-analysis was conducted by the RevMan 5.2 software, odds ratio （OR） with 95% confidence interval （CI） were calculated. Publication bias was identified using Stata 12.0 software. Results A total of 724 cases from 6 case-control trials were included. The results of Meta-analysis showed the different statistical significance was found between GSTP1 IlelO5Val polymorphism and clinical response in the follow genotypes [GG＋GAvs AA： 0R=2.38, 95%CI （1.29 -4.38）; GGvs GA＋AA： 0R=3.66, 95%CI （1.18 11.39） ; GG vs AA ： OR = 4.42, 95% CI （ 1.28 - 15.26 ） ] and Asian population subgroups [ GG ＋ GA vs AA ： OR =2.93, 95%CI （1.33 -6.48） ]. Conclusion Polymorphism of GSTP1 Ilel05Val（A/G） may be associ- ated with platinum-based chemosensitivity in advanced gastric cancer.