中文摘要：

目的评价吸烟与非吸烟慢性牙周炎患者牙周基础治疗1个月后的疗效差异。方法选择36例慢性牙周炎患者，吸烟组20例，非吸烟组16例，基线时两组牙周炎病情相似。从牙列的4个象限选取探诊深度在5-9nm，范围的位点1-2个，吸烟组108个位点，非吸烟组88个位点，观察这些位点在牙周基础治疗前、治疗后1个月临床指标的变化，包括菌斑指数（PH），牙龈出血指数（BI），牙周袋探诊深度（PPD）和附着丧失（AL）；在作临床观察的同时，对治疗前后龈沟液白介素（IL）-18进行检测。结果治疗前（基线时）两组PH、BI、PPD、AL以及IL—1β差异不显著，牙周基础治疗1个月后，两组的各项指标均有明显的改善，但吸烟组改善程度明显低于非吸烟组（P〈0．05）。结论慢性牙周炎患者，吸烟者牙周基础治疗的效果差于非吸烟者。

英文摘要：

Objective To evaluate the clinical effects of smoking on the response to initial periodontal therapy. Methods 20 smokers and 16 non-smokers with moderate to severe chronic periodontitis were chosen for the study. Clinical parameters including plaque index （PLI）, bleeding index （BI）, probing pocket depth （PPD）, attachment loss （AL）, and the concentration of gingival crevicular fluid （GCF） IL-1β were measured at one to two deepest sites （PD 5-9mm） of four quarters of dentition of the patients before aod one month after initial non-surgery treatment. The total 108 target sites from smokers and 88 target sites from non-smokers were involved in this study. Results There was no difference between smokers and non-smokers regarding PLI, BI, PPD, AL and GCF IL-1β at base line. After one month of initial periodontal treatment, means of PLI, BI, PPD, AL and GCF IL-1β were significantly higher in smokers than those in non-smokers （ P 〈 0.05）. Conclusion Smoking has negative effects on the host response to initial periodontal therapy.