目的:探讨健康人唾液中粘膜相关上皮趋化因子CCL28与sIgA抗体分泌的关系。方法:收集非刺激性全唾液,用酶联免疫吸附试验(ELISA)定量检测唾液中ECL28的含量。速率散射比浊方法定量检测唾液中sIgA的含量。结果:42例健康人唾液中所含CCL28的浓度平均值为(70.70±40.91)ng/ml,sIgA的浓度平均值为(113.86±54.90)mg/L,两者之间存在线性正相关关系(r=0.540)。结论:粘膜上皮趋化因子CCL28对唾液中sIgA的分泌起促进作用。
Objective: To evaluate the correlation between the mucosal epithelial chemokine CCL28 and sIgA level in the saliva of healthy humans. Methods: Unstimulated whole saliva samples were collected. The CCL28 level was determined by ELISA. The salivary slgA was measured by rate nephelometry assay. Results: In saliva samples of 42 healthy human beings, the mean value of salivary CCL28 was 70.70 ± 40.91 ng/ml, and of salivary sIgA was 113.86 ±54.90 mg/L. A positive linear correlation was noted between CCL28 and sIgA in saliva ( r = 0.540). Conclusion: The mucosal epithelial chemokine CCL28 can promote the secretion of sIgA in saliva.