组织修复涉及一系列复杂的生理学、免疫学及细胞生物学过程。研究表明,受损组织周围存在着一定强度的内源性电场,类似生理强度的外源性电场能指导细胞定向迁移、控制细胞极化、调节细胞增殖和分化等一系列生物学行为。该文针对外源性电场在伤口愈合、骨组织愈合以及血管新生过程中的细胞生物学作用及其对修复过程中组织水平的影响进行综述,以期为外源性电场在今后临床中的应用提供参考。
Tissue repair is a complicated process, which requires a complex interplay of diverse physiologi- cal, immunological and cell biological process. It has long been known that the endogenous electric fields exist at fresh wounds. Mimic experiments have shown that electric fields play a direction guidance in cell migration, polar- ization, proliferation and differentiation in wound healing. In this paper, we reviewed the advance of extracellular electrical fields guid cell migration, polarization and proliferation in wound healing, bone healing and revascular- ization, which might be a potential way in tissue repair.