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中文摘要：
建立了抗肿瘤肽AP-9的Fmoc固相全合成方法，产品纯度大于98％。着重研究了Fmoc-Arg（Pbf）-OH与H—Pro—Trt树脂的缩合反应。结果表明，以THF-NMP（1：1）为溶剂，于30℃微波辐射反应6min，缩合产率达80．2％。
英文摘要：
Antitumor peptide AP-9 （YKLPGHHHHYRP） was synthesized by Fmoc-solid phase peptide synthesis, and the purity of the product was more than 98 %. The coupling reaction between the difficult sequence Fmoc- Arg （Pbf）-OH and H-Pro-Trt resin was investigated. The results showed that the coupling reaction could be completed when it was carried out for 6min at 30℃ by microwave irradiation with THF-NMP （1 ： 1） as the solvent, and the yield could reach to 80.2 %.
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