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中文摘要：
气道黏液高分泌是慢性气道炎症疾病的一个重要病理生理特征,它直接影响着许多这类患者的发病率和病死率.大环内酯类抗生素对抑制气道黏液高分泌具有重要的作用,它通过干扰细胞内的各种信号转导,从而减少MUC5AC的合成和分泌.由于大环内酯类药物这种有别于其他抗生素的抗菌外效应,使得大环内酯类抗生素对于慢性气道炎症患者的治疗具有独特意义.
英文摘要：
Airway mucus hypersecretion,which contributes to morbidity and mortality of patient,is an important pathophyisological characteristic of many chronic inflammation diseases. Macrolide antibiotics have an important effect for inhibiting the airway mucus hypersecretion. Macrolide antibiotics can interrupt many intracellular signal transduction channels,then reduce synthesis and secertion of MUC5AC. Due to this effect, which deffer the others, Macrolide antibiotics have a unusual sense for the patient of chronic inflammation diseases.
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