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中文摘要：
慢性气道炎症性疾病以气道炎症反应、气道重塑、黏液高分泌等为主要病理特征。核受体为配体活化的转录因子，可降低气道高反应性，减轻炎性细胞和因子所致的气道炎症，减少黏液分泌等，在慢性气道炎性疾病的发生发展过程中起着重要的作用。核受体可单独或相互联系而发挥作用，亦可与其他转录因子进行交互通话。因此，深入研究核受体及其配体的作用将为慢性气道炎症性疾病展现广阔的治疗前景。
英文摘要：
The predominant pathological characteristics of the chronic airway inflammation are airway inflammation, airway remodeling, mucous hypersecretion and so on. Nuclear receptors are transcriptional factors activated by their ligands and play a significant role in the course of chronic airway inflammation, such as reducing airway hyperresponsiveness, relieving airway inflammation induced by inflammatory cells and factors, and decreasing mucous hypersecretion. Nuclear receptors can act alone or interact on each other, and they can also crosstalk with other transcriptional factors. Therefore, further investigation of nuclear receptors and their ligands may reveal a novel potential therapeutic prospect for chronic airway inflammation.
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