中文摘要：

目的探讨与子宫内膜异位症（EMS）相关性不孕患者卵母细胞发育潜能相关的代谢物组。方法利用超高效液相色谱．质谱（HPLGMS）对接受体外受精（BrF）的EMS相关性不孕患者即EMS组（n=27）和同期因男方因素行体外受精的健康妇女即对照组（n=28）进行卵泡液代谢组学分析。结果共观察到与EMS相关性不孕密切相关的差异代谢物28种，主要有脂类、核苷酸类、蛋白降解片段及其它等四大类。其中上调的代谢物主要有Valyl-Arginine、Methyl-15．cyanopentadecanoate、4-Oxo-13．cis-retinoate等15种；下调的代谢物主要有Menadioldibutyrate、3-hydroxynonanoylcamitine、Phytosphingosine等13种。结论本研究发现并描绘出两组卵泡液差异性代谢物谱，这28种代谢物组可能成为预测EMS妇女卵母细胞早期发育潜能的重要生物标志物。然而，并未见其与随后的胚胎质量、累积妊娠率以及活产率间明显的相关性。

英文摘要：

Objective To investigate metabolites associated with oocyte developmental potential in infertile patients with endomcaiosis （EMS）. Methods The metabolic analysis of follicular fluid was performed on 27 EMS-related infertility patients receiving in vitro fertilization （observation group） and 28 healthy women who underwent IVF due to male factor （control group） by ultra performance liquid chromatography-mass spectrometry （HPLC-MS）. Results There were 28 mctabolites, which were closely related to infertility associated with EMS. They were divided into four categories, including lipids, nucleotides, protein degradation fragments and the others. Fifteen metabolites such as Valyl-Arginine, Methyl-15-cyanopentadecanoate and 4-Oxo- 13-cis-retinoate were up-regulated; Menadiol dibutyrate, 3-liydroxy pentanoyl camitine, Phytosphingosine and other 13 metabolites were down-regulated. Conclusions In this study, we found and mapped the differential metabolite profiles of follicular fluid in the two groups, which may be an important biomarker for predicting the early developmental potential of EMS women oocytes. However, we did not fred a significant correlation between subsequent embryonic quality, cumulative pregnancy rate and live birth rate.