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中药复方改善子宫内膜异位症相关性不孕症妊娠率的系统评价
  • ISSN号:1673-6613
  • 期刊名称:《世界中西医结合杂志》
  • 时间:0
  • 分类:R711.71[医药卫生—妇产科学;医药卫生—临床医学]
  • 作者机构:[1]山东中医药大学,山东济南250014, [2]山东中医药大学附属医院中西医结合生殖与遗传中心,山东济南250014
  • 相关基金:国家自然科学基金(81373676); 山东省科技发展计划项目(2014GSF119021)
中文摘要:

全面检索自建刊至2015年公开发表在国内外杂志上以中药复方为主治疗子宫内膜异位症(EMT)相关性不孕症的相关文献,筛选出符合纳入标准的临床随机对照试验,使用Revman 5.3软件合并临床异质性较小的文献并进行Meta分析,比较中药复方与西药在改善EMT相关性不孕症妊娠率方面的疗效。结果纳入研究12项,共633例EMT相关性不孕患者,Meta分析显示,中药复方与西药相比,在改善EMT相关性不孕症妊娠率方面有很大优势。但是,由于语种限制,存在文献检索选择偏倚;阳性结果易于发表使纳入研究存在潜在发表偏倚;由于各家对内异症辨证分型存在差异,致使本次研究有潜在的信息偏倚。中药复方可有效改善EMT相关性不孕症妊娠率,且副作用小于西药,但由于纳入病例数量少且文献质量不高,故尚需更多高质量随机对照研究来证实。

英文摘要:

The literatures on endometriosis-associated infertility( EAI) treated with compound Chinese herbal formula were retrieved from the journals at home and abroad till 2015 since the establishment of journals. The RCTs were screened in compliance with the inclusive criteria. Meta analysis was done with Revman 5. 3 and on the literatures with less clinical heterogeneity. The therapeutic effect on the improvement of pregnancy rate in EAI patients was compared between compound Chinese herbal formula and western medicine. Totally 12 RCTs were included with 633 cases of EAI involved. Meta analysis showed that compound Chinese herbal formula was very advantageous at the improvement of pregnancy rate in EAI as compared with western medicine. But,due to language limitation,the selection bias happens. The positive results were easily published,resulting in the potential publication bias in the included RCT. Because of the difference in the syndrome differentiation of endometriosis,the information bias was potentially occurred in the study. The compound Chinese herbal formula improves effectively the pregnancy rate in EAI and its side effects are less than western medicine. But,due to less number of included cases and low quality of literature,it needs much more high-quality RCTs for verification.

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期刊信息
  • 《世界中西医结合杂志》
  • 中国科技核心期刊
  • 主管单位:中国科学技术协会
  • 主办单位:中华中医药学会
  • 主编:路志正
  • 地址:北京市朝阳区北土城西路11号北京城建开发大厦东座303室
  • 邮编:100101
  • 邮箱:sjzxyjh@126.com
  • 电话:010-82275991
  • 国际标准刊号:ISSN:1673-6613
  • 国内统一刊号:ISSN:11-5511/R
  • 邮发代号:80-538
  • 获奖情况:
  • 第四届全国中医药优秀期刊二等奖,中年中医药学会中医药标志性文化(徽标)一等奖,获中国简直协精品科技期刊工程项目赞助国外数...,美国<<乌利希期刊指南>>收录
  • 国内外数据库收录:
  • 英国农业与生物科学研究中心文摘,波兰哥白尼索引,美国剑桥科学文摘,中国中国科技核心期刊
  • 被引量:13993