全面检索自建刊至2015年公开发表在国内外杂志上以中药复方为主治疗子宫内膜异位症(EMT)相关性不孕症的相关文献,筛选出符合纳入标准的临床随机对照试验,使用Revman 5.3软件合并临床异质性较小的文献并进行Meta分析,比较中药复方与西药在改善EMT相关性不孕症妊娠率方面的疗效。结果纳入研究12项,共633例EMT相关性不孕患者,Meta分析显示,中药复方与西药相比,在改善EMT相关性不孕症妊娠率方面有很大优势。但是,由于语种限制,存在文献检索选择偏倚;阳性结果易于发表使纳入研究存在潜在发表偏倚;由于各家对内异症辨证分型存在差异,致使本次研究有潜在的信息偏倚。中药复方可有效改善EMT相关性不孕症妊娠率,且副作用小于西药,但由于纳入病例数量少且文献质量不高,故尚需更多高质量随机对照研究来证实。
The literatures on endometriosis-associated infertility( EAI) treated with compound Chinese herbal formula were retrieved from the journals at home and abroad till 2015 since the establishment of journals. The RCTs were screened in compliance with the inclusive criteria. Meta analysis was done with Revman 5. 3 and on the literatures with less clinical heterogeneity. The therapeutic effect on the improvement of pregnancy rate in EAI patients was compared between compound Chinese herbal formula and western medicine. Totally 12 RCTs were included with 633 cases of EAI involved. Meta analysis showed that compound Chinese herbal formula was very advantageous at the improvement of pregnancy rate in EAI as compared with western medicine. But,due to language limitation,the selection bias happens. The positive results were easily published,resulting in the potential publication bias in the included RCT. Because of the difference in the syndrome differentiation of endometriosis,the information bias was potentially occurred in the study. The compound Chinese herbal formula improves effectively the pregnancy rate in EAI and its side effects are less than western medicine. But,due to less number of included cases and low quality of literature,it needs much more high-quality RCTs for verification.