欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
流感是由流感病毒引起的一种严重影响人类生命健康的传染性疾病。神经氨酸酶是流感病毒表面的一种重要糖蛋白，在病毒的复制周期中起着关键作用，是抗流感病毒合理药物设计的理想靶点。自2006年以来，结构生物学研究发现了神经氨酸酶新的配体结合位点，为新型神经氨酸酶抑制剂的设计提供了依据。本文综述了靶向于神经氨酸酶新结合位点的抑制剂的研究。
英文摘要：
Influenza, which is caused by influenza virus, is a great threat to human health. Neuraminidase is an important surface glycoprotein of influenza virus and plays a critical role in the viral replicative cycle. Therefore,it is an attractive target for the rational design of anti-influenza drugs. Several novel ligand binding sites of viral neuraminidase have been identified since the year of 2006, which paved way for the design of novel neuraminidase inhibitors. Herein, the research progress of neuraminidase inhibitors targeting these novel binding sites were reviewed.
同期刊论文项目
同项目期刊论文
Fused heterocyclic compounds bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 1: Design, syn
Design, synthesis and preliminary SAR studies of novel N-arylmethyl substituted piperidine-linked an
Design, synthesis and biological evaluation of N-2,N-4-disubstituted-1,1,3-trioxo-2H,4H-pyrrolo[1,2-
Design, synthesis and biological evaluation of novel ligustrazinylated derivatives as potent cardiov
Discovery of 2-pyridone derivatives as potent HIV-1 NNRTIs using molecular hybridization based on cr
Discovery of novel 2-(3-(2-chlorophenyl)pyrazin-2-ylthio)-N-arylacetamides as potent HIV-1 inhibitor
The HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors (Part V-star): Capravirine and Its Analogu
Design, synthesis and biological evaluation of 3-benzyloxy-linked pyrimidinylphenylamine derivatives
Discovery of nitropyridine derivatives as potent HIV-1 non-nucleoside reverse transcriptase inhibito
Discovery of novel diarylpyrimidines as potent HIV NNRTIs via a structure-guided core-refining appro
Facile Synthesis of Derivatives of 1,1,3-Trioxo-2H,4H-pyrrolo[1,2-b][1,2,4,6]thiatriazine: A New Het
Arylazolyl(azinyl)thioacetanilides. Part 10: Design, synthesis and biological evaluation of novel su
Synthesis and Anti-HIV Activity Evaluation of 2-(5-(Naphthalen-1-yl)-1,2,3-thiadiazol-4-ylthio)-N-ac
Arylazolylthioacetanilide. Part 11: Design, synthesis and biological evaluation of 1,2,4-triazole th
Synthesis and biological evaluation of piperidine-substituted triazine derivatives as HIV-1 non-nucl
Discovery of Novel 2-(3-(2-Chlorophenyl) pyrazin-2-ylthio)-N-arylacetamides As Potent HIV-1 Inhibito
Benzimidazole (Benzimidazolone) Heterocycle as A Privileged Scaffold in Antiviral Agents. Mini-Revie
Synthesis and biological evaluation of novel 5-alkyl-2-arylthio-6-((3,4-dihydroquinolin-1(2H)-yl)met
Facile Synthesis of Derivatives of 1,1,3-Trioxo-2H,4H-pyrrolo[1,2-b] [1,2,4,6]thiatriazine: A New He
Arylazolylthioacetanilide. Part 8: Design, synthesis and biological evaluation of Novel 2-(2-(2,4-Di
1,2,3-thiadiazole thioacetanilides. Part 2: Synthesis and biological evaluation of a new series of 2
Design, synthesis, anti-HIV evaluation and molecular modeling of piperidine-linked amino-triazine de
Arylazolyl(azinyl)thioacetanilide. Part 9: Synthesis and biological investigation of thiazolylthioac
Xiao Li, Peng Zhan*, Hong Liu, Dongyue Li, Liu Wang , Xuwang Chen, Huiqing Liu, Christophe Pannecouq
The HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors (Part V): Capravirine and Its Analogues. C
Strategies for the design of HIV-1 non-nucleoside reverse transcriptase inhibitors: lessons from the
Structure-based bioisosterism design, synthesis and biological evaluation of novel 1,2,4-triazin-6-y
Discovery of novel pyridazinylthioacetamides as potent HIV-1 NNRTIs using a structure-based bioisost
Design, synthesis and biological evaluation of novel 3,5-disubstituted-1,2,6-thiadiazine-1,1-dione d
Design, synthesis and biological evaluation of N2, N4-disubstituted- 1,1,3-trioxo-2H,4H-pyrrolo[1,2-
Diwakar Rai,Wenmin Chena, Ye Tian, Xuwang Chen,Peng Zhan, Erik De Clercq, Christophe Pannecouque, Ja
Synthesis and anti-HIV activity evaluation of novel N1-arylidene-2-[1-(naphthalen-1-yl)-1H-tetrazol-
Synthesis and Biological Evaluation of 6-Substituted 5-Alkyl-2-(phenylaminocarbonylmethylthio)pyrimi
Discovery of Piperidine-Linked Pyridine Analogues as Potent Non-nucleoside HIV-1 Reverse Transcripta
Recent Advances in the Research of 2,3-Diaryl-1,3-thiazolidin-4-one Derivatives as Potent HIV-1 Non-
Novel Piperidinylamino-diarylpyrimidine Derivatives with Dual Structural Conformations as Potent HIV
Synthesis and Anti-HIV Evaluation of Novel 1,2,4-triazole Derivatives as Potential Non-nucleoside HI
期刊信息
位置：