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新型HEPT类HIV-1非核苷类逆转录酶抑制剂的设计、合成与活性研究
  • 项目名称：新型HEPT类HIV-1非核苷类逆转录酶抑制剂的设计、合成与活性研究
  • 项目类别：国际(地区)合作与交流项目
  • 批准号：30910103908
  • 项目来源：国家自然科学基金
  • 研究期限：1900-01-01-1900-01-01
  • 项目负责人：刘新泳
  • 依托单位：山东大学
  • 批准年度：2009
成果综合统计
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  • 期刊论文
  • 会议论文
  • 专利
  • 获奖
  • 著作
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期刊论文
抗艾滋病药物设计新策略:多靶点及多价态结合配体
Arylazolylthioacetanilide. Part 11: Design, synthesis and biological evaluation of 1,2,4-triazole th
Synthesis and biological evaluation of piperidine-substituted triazine derivatives as HIV-1 non-nucl
Discovery of Novel 2-(3-(2-Chlorophenyl) pyrazin-2-ylthio)-N-arylacetamides As Potent HIV-1 Inhibito
Benzimidazole (Benzimidazolone) Heterocycle as A Privileged Scaffold in Antiviral Agents. Mini-Revie
Synthesis and biological evaluation of novel 5-alkyl-2-arylthio-6-((3,4-dihydroquinolin-1(2H)-yl)met
Facile Synthesis of Derivatives of 1,1,3-Trioxo-2H,4H-pyrrolo[1,2-b] [1,2,4,6]thiatriazine: A New He
Arylazolylthioacetanilide. Part 8: Design, synthesis and biological evaluation of Novel 2-(2-(2,4-Di
1,2,3-thiadiazole thioacetanilides. Part 2: Synthesis and biological evaluation of a new series of 2
Design, synthesis, anti-HIV evaluation and molecular modeling of piperidine-linked amino-triazine de
Arylazolyl(azinyl)thioacetanilide. Part 9: Synthesis and biological investigation of thiazolylthioac
Synthesis, drug release and anti-HIV activity of a series of PEGylated zidovudine conjugates
Recent Progress in Small Molecule CCR5 Antagonists as Potential HIV-1 Entry Inhibitors
病毒蛋白的核输入过程:抗HIV-1药物研究的新靶点
亲环素A:艾滋病治疗的潜在靶点
处于临床试验中的小分子趋化因子受体5拮抗剂
小分子CCR5拮抗剂研究进展
New Therapeutic Approaches Targeted at the Late Stages of the HIV-1 Replication Cycle
Xiao Li, Peng Zhan*, Hong Liu, Dongyue Li, Liu Wang , Xuwang Chen, Huiqing Liu, Christophe Pannecouq
The HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors (Part V): Capravirine and Its Analogues. C
Current drug research on PEGylation with small molecular agents
Strategies for the design of HIV-1 non-nucleoside reverse transcriptase inhibitors: lessons from the
Structure-based bioisosterism design, synthesis and biological evaluation of novel 1,2,4-triazin-6-y
Recent Advances of Diaryl Ether Family as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors
Discovery of novel pyridazinylthioacetamides as potent HIV-1 NNRTIs using a structure-based bioisost
Diwakar Rai,Wenmin Chena, Ye Tian, Xuwang Chen,Peng Zhan, Erik De Clercq, Christophe Pannecouque, Ja
HIV-1 NNRTIs: Structural diversity, pharmacophore similarity, and impliations for drug design
Rationally designed multitarget anti-HIV agents
Synthesis and anti-HIV activity evaluation of novel N1-arylidene-2-[1-(naphthalen-1-yl)-1H-tetrazol-
Targeting Protein-Protein Interactions: A Promising Avenue of Anti-HIV Drug Discovery
Blocking Nuclear Import of Pre-Integration Complex: An Emerging Anti-HIV-1 Drug Discovery Paradigm
HIV-1衣壳蛋白抑制剂的研究进展
Discovery of Dihydro-Alkyloxy-Benzyl-Oxopyrimidines as Promising Anti-Influenza Virus Agents
Functional Roles of Azoles Motif in Anti-HIV Agents
Discovery of Piperidine-Linked Pyridine Analogues as Potent Non-nucleoside HIV-1 Reverse Transcripta
Novel Piperidinylamino-diarylpyrimidine Derivatives with Dual Structural Conformations as Potent HIV
Retroviral Restriction Factors TRIM5 alpha: Therapeutic Strategy to Inhibit HIV-1 Replication
Synthesis and Anti-HIV Evaluation of Novel 1,2,4-triazole Derivatives as Potential Non-nucleoside HI
Synthesis and biological evaluation of pyridazine derivatives as novel HIV-1 NNRTIs
TSG101: A Novel Anti-HIV-1 Drug Target
The Development of HEPT-Type HIV Non-Nucleoside Reverse Transcriptase Inhibitors and Its Implication
Synthesis, In Vitro and In Vivo Release Kinetics, and Anti-HIV Activity of A Sustained-Release Prodr
Multivalent Agents: A Novel Concept and Preliminary Practice in Anti-HIV Drug Discovery
Recent Advances in the Research of 2,3-Diaryl-1,3-thiazolidin-4-one Derivatives as Potent HIV-1 Non-
Recent Advances in DAPYs and Related Analogues as HIV-1 NNRTIs
Synthesis and Biological Evaluation of 6-Substituted 5-Alkyl-2-(phenylaminocarbonylmethylthio)pyrimi
Recent Advances in the DABOs Family as Potent HIV-1 non-Nucleoside Reverse Transcriptase Inhibitors
Design, synthesis and biological evaluation of N2, N4-disubstituted- 1,1,3-trioxo-2H,4H-pyrrolo[1,2-
Design, synthesis and biological evaluation of novel 3,5-disubstituted-1,2,6-thiadiazine-1,1-dione d
结构优化策略在HIV非核苷类逆转录酶抑制剂设计中的应用
Privileged Scaffolds or Promiscuous Binders: A Glance of Pyrrolo[2,1-f][1,2,4]triazines and Related
Cosalane and its Analogues: A Unique Class of Anti-HIV Agents
会议论文
芳嗪巯乙酰胺类HIV-1 NNRTI的设计、合成及活性评价
抗耐药性HIV-1非核苷类逆转录酶抑制剂的设计、合成与活性研究
HIV-1非核苷类逆转录酶抑制剂etravirine类似物的设计、合成与活性评价
不同分子量聚乙二醇修饰齐多夫定缀合物的合成、体外释放、药代动力学及抗HIV活性的研究
二氢烷氧苄基嘧啶酮类HIV-1 NNRTIs的设计、合成及活性研究
刘新泳的项目
噻吩并噻二嗪新型非核苷类HIV逆转录酶抑制剂的研究
期刊论文 49 会议论文 4 著作 1
取代噻二嗪类HIV-1非核苷类逆转录酶抑制剂的设计、合成与活性研究
期刊论文 33 会议论文 10
新型六元芳杂环类抗耐药性HIV-1 NNRTI的设计、合成与活性研究
期刊论文 3
吡咯并噻三嗪类HIV-1非核苷类逆转录酶抑制剂的设计、合成与活性研究
期刊论文 42 会议论文 6
多位点结合型流感病毒神经氨酸酶抑制剂的设计、合成与活性评价
含噻二嗪杂环新型碱基核苷酸类HIV逆转录酶抑制剂的设计、合成与活性研究
期刊论文 1