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中文摘要：
RNA聚合酶是由PA、PB1和PB2三个亚基构成的蛋白质复合物,在流感病毒基因组的转录复制过程中发挥着重要作用。随着研究的不断深入,RNA聚合酶已经成为抗流感病毒药物重要的靶点。本文介绍了RNA聚合酶各个亚基结构、功能以及RNA聚合酶抑制剂的研究进展。
英文摘要：
The influenza virus polymerase（P complex） is a heterotrimer with the subunits PA,PB1 and PB2,which plays important roles in both viral mRNA transcription and replication.Extensive biochemical and virological as well as recent structural studies of this enzyme have provided opportunities for the design and discovery of the RNA polymerase inhibitors against influenza viral replication.This review described the research progress about RNA polymerase subunits on its structure,function and inhibitors.
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