中文摘要：

为比较鸽源VIb亚型新城疫病毒（NDV）与其它不同基N型NDV对鸽的致病性差异，本研究选取JS-7-05-Ch（基因型）、WX-10-07-Pi（基因VIb型）、JS-5-05-Go（基因Ⅶd型）和F48E8（基因IX型）4个病毒株，分别人工感染2月龄实验鸽。接种后，观察实验鸽临床症状、病理剖解变化、同时检测HI抗体水平变化、喉气管和泄殖腔排毒以及病毒在组织分布情况。4株NDV均能导致接种鸽的发病，但死亡率分别为0、0、100％、50％。WX-10—07-Pi接种组鸽泄殖腔排毒时间最长、而且病毒检出率比其它组高。另外，在接种组鸽的多种组织器官中均可检测出病毒。实验结果表明，不同基因型NDV对鸽均有致病性，但致病力强弱与NDV毒株特性有关；基因VIb型NDV在鸽体内可长期的带毒与排毒，与其它基因型NDV相比更易在鸽群中传播。

英文摘要：

To evaluate the pathogenicity of Newcastle disease virus （NDV） strains of different genotypes in pigeons, JS-7-05-Ch, WX-10-07-Pi, JS-5-05-Go and F48E8 NDV strains that belonged to genotype III, VI, VII and IX, respectively, were chosen to artificially infect two-month-old pigeons. Clinical symptoms and pathological changes of pigeons were observed, and humoral antibody response, virus shedding and virus distribution in tissues were examined. The results showed that NDVs could cause 100 % morbidity in pigeons and the mortality of pigeons infected with genotype III-, VI-, VII- and IX-infected groups was 0, 0, 100 % and 50 %, respectively. Pigeons infected with WX-10-07-Pi experienced longer time in virus shedding and showed higher ratio of virus isolation when compared with other pigeons, which indicated that the VIb NDVs might have genetic advantages over other genotypes in NDV outbreaks in pigeons.