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molecular logic computing model based on self-assembly of dna nanoparticles
  • ISSN号：1001-6538
  • 期刊名称：Chinese Science Bulletin
  • 时间：0
  • 页码：3566-3571
  • 分类：TP18[自动化与计算机技术—控制科学与工程;自动化与计算机技术—控制理论与控制工程] Q523[生物学—生物化学]
  • 作者机构：[1]Institute of Software, School of Electronics Engineering and Computer Science, Key Laboratory of High Confidence Software Technologies of Ministry of Education, Peking University, Beijing 100871, China, [2]Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100190, China
  • 相关基金：The authors sincerely acknowledge all the referee＇s suggestions for this paper. This work was supported by the National Natural Science Foundation of China （60910002, 61033003, 60974112, 60971085, and 30970969）, National High-Tech Research and Development Program of China （2009AAOIZ413）, Ph.D. Programs Foundation of the Ministry of Education of China （20070001020）, and the Postdoctoral Science Foundation of China （20100480128）.
  • 相关项目：活体生物分子计算模型的一些研究与探索
作者： zhang cheng|yangjing|xu jin|
关键词： DNA分子, 逻辑运算, 纳米粒子, 自组装, 运算模型, 颜色变化, 计算模型, DNA计算, logic computing, DNA computing, nanoparticle, DNA self-assembly
中文摘要：

在这份报纸，一个逻辑计算模型用 DNA nanoparticle 被构造，与 DNA/Au nanoparticle 的变化技术结合的颜色结合了，并且 DNA 计算。几种重要技术在这个分子的计算模型被利用：DNA 自己组装， DNA/Au nanoparticle 变化形式，和颜色变化源于 Au nanoparticle 聚集。简单逻辑计算模型被一个颜色变化认识到，源于 DNA 变化自己组装。基于这个计算模型，一套操作计算模型也被建立，由哪个一个简单逻辑问题被解决。扩大这个逻辑 nanocomputing 系统的应用程序，一个分子的察觉方法为 H1N1 被开发病毒基因察觉。

英文摘要：

In this paper, a logic computing model was constructed using a DNA nanoparticle, combined with color change technology of DNA/Au nanoparticle conjugates, and DNA computing. Several important technologies are utilized in this molecular computing model： DNA self-assembly, DNA/Au nanoparticle conjugation, and the color change resulting from Au nanoparticle aggregation. The simple logic computing model was realized by a color change, resulting from changing of DNA self-assembly. Based on this computing model, a set of operations computing model was also established, by which a simple logic problem was solved. To enlarge the applications of this logic nanocomputing system, a molecular detection method was developed for H1N1 virus gene detection.

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