中文摘要：

蛙皮降压肽（Sauvagine，Svg）是一种良好的促肾上腺皮质激素，释放因子2受体（CRF2R）激动剂，但它是一种非选择性激动剂，作用于CRF1R而产生副作用。为了探讨蛙皮降压肽类似物对CRF2R与CRF1R选择性的影响，本文使用正交因子（Orthogonal Factors，Orth-Factors）描述子，对45个蛙皮降压肽类似物与CRF2F、CRF1R的亲合力进行了QSAR研究，所建立的QSAR模型预测能力良好。通过QSAR模型信息，设计了17个蛙皮降压肽类似物，其中3个对CRF2R与CRF1R受体选择性良好（SQ：110，TQ：105，VQ：110），有进一步研究的价值。

英文摘要：

The sauvagine （Svg） is a good agonist for corticotropin Releasing Factor 2 Receptor （CRF2R）. Unfortunately, Svg is a nonselective CRFR agonist, thus making it of less utility due to side effects resulting from corticotropin release factor 1 receptor （CRF1 R） activation. In order to research the selectivity of Svg analogues for CRF2R and CRF1 R, the Orthogonal Factors （Orth-Factors） descriptors were used to characterize the Svg analogues and the QSAR model was constructed which reflect the interaction between Svg and CRF2R or CRF1R. The QSAR model has high performance prediction （CRF2R： R2 = 0. 633, Q2 = 0. 428; CRF1R： R2 = 0. 918, Q^2 =0. 770）. According to the information of QSAR model, 17 Svg analogues were designed including 3 peptides with high selectivity to CRF2R and CRF1R, and it is valuable to research these Svg analogues.