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中文摘要：
目的检测HPV L1和16/18DNA在喉癌组织中的表达,探讨HPV在喉癌发生中的作用。方法用原位杂交(ISH)检测123例喉癌组织及123例"正常人"的喉粘膜上皮组织中HPV-16/18 mRNA。结果在123例喉癌标本中,ISH检出HPV-16E6的阳性率为46.34%,HPV-18E6的阳性率为35.77%。123例"正常人"的喉粘膜ISH结果表明:低危型HPV的阳性率与喉癌相近;高危型HPV的阳性率虽远远低于喉癌,但随着组织病变程度加重阳性率逐渐升高。对上述结果用SPSS 10.0软件进行case-controlχ2分析,HPV-16感染会增加喉上皮病变的风险(OR=14.58),感染HPV-18时,喉上皮病变的风险(OR=10.77)。结论HPV-16感染是重庆地区喉癌的重要发病因素;HPV-16感染后E6片段的保留并持续表达与喉组织的癌变进程密切相关;HPV-16感染会增强喉上皮病变的风险,而HPV-18有协同作用。
英文摘要：
Objective To look for the further evidence for HPV16 E6 and HPV 18 E6 as carcinogenic factors in laryngeal carcinoma.Methods Representative number of specimens from laryngeal cancer were examined with highly sensitive in situ hybridization(ISH) technique for the presence of HPV and high-risk types HPV16 E6,HPV18 E6.Results In these specimens from patients,46.34% were HPV16 E6 positive and 35.77% were HPV-18E6 positive.ISH was used to screen the prevalence of HPV infection from "normal crowd",which was lower...
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