中文摘要：

最近的研究证明 pseudogenes 能由为 miRNAs 竞争调整他们的编码基因搭挡的表示。E2F 家庭戏在房间周期检查点的控制的一个关键角色。E2F3P1 是 E2F3 的 pseudogene。很少研究在 pseudogenes 上集中了于基因变化。在这研究，我们执行了盒子控制研究在 1050 肝炎 B 病毒(HBV ) 在 E2F3P1 和 hepatocellular 癌(HCC ) 风险估计在单个核苷酸多型性(SNP ) 之间的协会积极 HCC 盒子和 1050 个长期的 HBV 搬运人。逻辑回归分析被使用为在遗传型和 HCC 风险之间的协会估计机会比率(ORs ) 和 95% 信心间隔(CI ) 。我们发现 rs1838149 的变体 CT/TT 遗传型与 HCC 的显著地减少的风险被联系(调整或 = 0.66， 95% CI = 0.51-0.86， P = 0.002 ) 与那些相比与 wildtype CC 同质接合体。而且， rs9909601 的 AA 遗传型有增加的 HCC 风险与一调整或 1.41 (95% CI = 1.07-1.86 )，并且 rs9909601 的 A 等位基因显著地与 G 等位基因与那些相比与 HCC 风险被联系(调整或= 1.17 ，95% CI = 1.03-1.33 ， P = 0.017 )。这些结果显示在 pseudogene E2F3P1 的基因变化可以授与 HCC 风险。

英文摘要：

Recent studies showed that pseudogenes can regulate the expression of their coding gene partners by competing for miRNAs. The E2F family plays a crucial role in the control of cell cycle checkpoint. E2F3P1 is a pseudogene of E2F3. Few studies focused on genetic variations on pseudogenes. In this study, we performed a case-control study to assess the association between single nucleotide polymorphisms （SNPs） in E2F3P1 and hepatocellular carcinoma （HCC） risk in 1050 hepatitis B virus （HBV）-positive HCC cases and 1050 chronic HBV carders. Logistic regres- sion analysis was applied to estimate odds ratios （ORs） and 95% confidence intervals （CIs） for the associations between genotypes and HCC risk. We found that the variant CT/TT genotypes of rs1838149 were associated with a significantly decreased risk of HCC （adjusted OR = 0,66, 95% CIs = 0.51-0.86, P = 0.002） compared to those with wildtype CC homozygote. Furthermore, the AA genotype of rs9909601 had an increased HCC risk with an adjusted OR of 1.41 （95% CIs = 1.07-1.86）, and the A allele of rs9909601 was significantly associated with HCC risk com- pared to those with the G allele （adjusted OR = 1.17, 95% CIs = 1.03-1.33, P = 0.017）. These results indicate that genetic variations in the pseudogene E2F3P1 may confer HCC risk.