中文摘要：

大骨节病是一种地方性变形性骨关节病，至今病因未明，且尚无有效治疗措施，因此寻找早期生物学诊断标志物对于大骨节病的防治具有重要意义。本文通过文献回顾，结合近年来国际上在骨关节病方面的研究方法和进展，综述了大骨节病既往在代谢方面的研究以及通过代谢组学技术寻找生物标志和进行病因研究的前景。

英文摘要：

Kashin-Beck Disease（KBD） is an endemic and deforming osteochondropathy with unknown etiology, and without effective treatment measures up to now. It is significant to select the early biological markers for the diagnosis, prevention and treatment on KBD. Through a brief literature review of the international research methods and its development on osteoarthrosis in recent years, the paper summarizes the metabonomics development of KBD and its prospect in looking for the biomarkers.