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N-(4'-取代嘧啶-2'-基)-2-甲氧羰基-5-(取代)苯甲酰胺基苯磺酰脲化合物的合成及除草活性研究
  • 期刊名称：有机化学，2008，28(4)，649-656
  • 时间：0
  • 分类：TQ457.29[化学工程—农药化工] TQ463.2[化学工程—制药化工]
  • 作者机构：[1]南开大学元素有机化学研究所元素有机化学国家重点实验室,天津300071
  • 相关基金：国家自然科学基金（No.20432010）、国家973（No.2003CB114406）资助项目.
  • 相关项目：生物合理设计绿色农药的分子基础研究
关键词： 苯磺酰脲, 5-位取代苯环, 合成, 除草活性, benzene sulfonylurea, 5-substituted phenyl ring, synthesis, herbicidal activity
中文摘要：

为进一步寻找高效、安全和对环境更加友好的除草剂，以商品化除草剂单嘧磺酯为研究基础，对其结构中的苯环5-位取代基作了结构修饰，合成了26个未见文献报道的新型N-（4’-取代嘧啶-2’-基）-2-甲氧羰基-5-苯甲酰胺基苯磺酰脲化合物，通过^1HNMR、质谱及元素分析确定了化合物的结构．经油菜平皿法及盆栽法测试了所有化合物的除草活性，结果表明，当苯环5-位取代基为苯甲酰胺时，活性较好，其对双子叶植物的除草活性与商品化的甲嘧磺隆相当．

英文摘要：

In order to search for ecologically-safer and environmentally-benign sulfonylurea herbicides, on the basis of study on the N-（4-methylpyrimidin-2-yl）-N＇（2-methoxycarbonyl phenylsulfonyl）urea, named monosulfuron, a commercialized herbicide invented by our laboratory, 26 novel benzenesulfonylurea compounds modified at the 5-position of the benzene ring were synthesized. The structures of all compounds synthesized were confirmed by elemental analysis, MS and ^1H NMR spectra. Herbicidal activity of the new compounds was determined by rape disc and pot bioassay experiments. The result indicated that when the substituent group at 5-position of the benzene ring was benzamide, the herbicidal activity was good compared to sulfometuron-methyl.

同期刊论文项目
生物合理设计绿色农药的分子基础研究
期刊论文 141 会议论文 29
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