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含1，2，4-三唑杂环的新型Strobilurins衍生物的合成及杀菌活性
  • ISSN号：0253-2786
  • 期刊名称：《有机化学》
  • 时间：0
  • 分类：O641.4[理学—物理化学;理学—化学] TQ455.47[化学工程—农药化工]
  • 作者机构：[1]华中师范大学化学学院农药与化学生物学教育部重点实验室,武汉430079
  • 相关基金：国家自然科学基金（Nos.20432010,20476036,20172017）、教育部跨世纪优秀人才资助计划、教育部重点科技项目及湖北省优秀创新群体（No.2004ABC002）资助项目.
作者： 赵培亮[1], 章博[1], 王亚洲[1], 杨光富[1]
关键词： STROBILURINS, 杀菌活性, 晶体结构, strobilurins, fungicidal activity, crystal structure
中文摘要：

为了寻找新的高活性先导化合物，设计合成了14个未见文献报道的Strobilurins类衍生物，结构经MS，^1H NMR，元素分析确认．并用X—ray单晶衍射测定了（E）-3-甲氧基-2[（5-甲基-4-邻溴代苯亚甲基亚胺基-1，2，4-三唑）-3-硫亚甲基]-苯基丙烯酸甲酯（5i）的晶体结构，证实了分子中的两个C=C均为E-式构型．初步生物活性测试结果表明，在实验浓度下部分化合物具有一定的杀菌活性．

英文摘要：

In order to find highly active lead compounds, fourteen novel derivatives of strobilurins were designed and synthesized. Their structures were characterized by MS, ^1H NMR spectra and elemental analysis. The single crystal structure of compound 5i was determined by X-ray diffraction analysis, which revealed that the two carbon-carbon double bonds in the molecule were of E,E-configurations. The preliminary bioassay showed that some of them exhibited certain fungicidal activities.

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期刊信息
  • 《有机化学》
  • 中国科技核心期刊
  • 主管单位:
  • 主办单位:中国化学会 中国科学院上海有机化学研究所
  • 主编：陈庆云
  • 地址：上海市枫林路354号
  • 邮编：200032
  • 邮箱：bianji@mail.sioc.ac.cn
  • 电话：021-54925244
  • 国际标准刊号：ISSN：0253-2786
  • 国内统一刊号：ISSN：31-1321/O6
  • 邮发代号:4-285
  • 获奖情况:
  • 中国期刊方阵“双效”期刊
  • 国内外数据库收录:
  • 俄罗斯文摘杂志,美国化学文摘（网络版）,荷兰文摘与引文数据库,美国科学引文索引（扩展库）,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊（2004版）,中国北大核心期刊（2008版）,中国北大核心期刊（2011版）,中国北大核心期刊（2014版）,中国北大核心期刊（2000版）
  • 被引量:14408