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中文摘要：
以5，7-二甲基-1，2，4-三唑并[1，5-a]嘧啶-2-甲硫醚为起始原料，设计合成了15个新型的5，7-二甲基-1，2，4-三唑并[1，5-a]嘧啶-2-氧乙酰腙及10个（月）-5，7-二甲基-1，2，4-三唑并[1，5-a]嘧啶-2-氧（α-甲基）乙酰腙类化合物，通过元素分析、MS和^1H NMR对所合成的化合物进行了结构表征．初步生物活性测试结果表明，部分化合物表现出不同程度的除草及杀菌活性．目标化合物中引入手性中心有利于生物活性的提高．
英文摘要：
Fifteen novel 5,7-dimethyl-1,2,4-triazolo[ 1,5-a]pyrimidine-2-oxoacetohydrazone derivatives and ten novel （ R ） -5,7-dimethyl-1,2,4-triazolo [ 1,5-a ] pyrimidine-2-oxo （ α-methyl ） acetohydrazone derivatives were designed and synthesized by using 5,7-dimethyl-1,2,4-triazolo [ 1,5-a ] pyrimidine-2-methylthioether as the starting material. All synthesized compounds were confirmed by elemental analysis, MS and ^1H NMR. The preliminary bioassay indicates that some of them display good herbicidal and fungicidal activities. Those compounds with chiral center display better bioactivities.
同期刊论文项目
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Design and synthesis of novel anthranilic diamides containing 5,7-dimethyl[1,2,4]triazolo[1,5- a]pyr
Binding Model Construction of Antifungal 2-Aryl-4- Chromanones Using CoMFA, CoMSIA and QSAR Analyses
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Synthesis, Fungicidal and Insecticidal Activities of β-Methoxyacrylate-Containing N-Acetyl Pyrazolin
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Construction of a Combinatorial Library of 2-(4-Oxo-4H-1-Benzopyran-3-yl)-4-Thiazolidinones By Micro
Microwave-Assisted, One-Pot Syntheses and Fungicidal Activity of Polyfluorinated 2-BenzylthioBenzoth
Syntheses and Crystal Structures of (S)-Methyl 2-(4-R- phenylsulfonamido)-3-(1H-indol-3-yl)propanoat
Synthesis, Bioactivity and SAR study of N'-(5-substituted- 1,3,4-thiadiazol-2-yl)- N-cyclopropylform
Interactions of Aryloxyphenoxypropionic Acids with Sensitive and Resistant Acetyl-Coenzyme A Carboxy
Enzymatic synthesis of cyclohexyl-α and β-D-glucosides catalyzed by α- and β-glucosidase in a biphas
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An Efficient Intramolecular Stetter Reaction in Room Temperature Ionic Liquids Promoted By Microwave
A Selective Transformation of Flavanones to 3-Bromoflavones and Flavones Under Microwave Irradiation
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Development of a general quantum-chemical descriptor for steric effects: Density functional theory b
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Synthesis and spectroscopic characterization of binaphthol aminosugars for stimulation of DNA strand
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