中文摘要：

我们在 vivo 调查了 T 房间的反应到 staphylococcal 肠毒素 A (海) 注射。我们发现有 10 亩陷阱的最佳的剂量的海的单个注射显著地弄皱 CD4 和 CD8 的表示。在在注射之间的海重新注射和时间间隔强烈影响了 CD4~+ 和 CD8~+T 房间的应答的海角以后，有在 vivo 的海反应的 Tcells 的扩大。T 房间的变应力缺乏在三 SEAtreatments 以后被观察。在注射之间的时间间隔主要影响了 CD4~+ Tcells，不是 CD8~+ T 房间的无答复的海角。CD4~+ T 房间的变应力缺乏跟随的显著删除在短间隔被导致，并且没有 CD4~+ T 房间的明显的删除的变应力缺乏在长间隔被导致。Wealso 发现 anergic 状态在 vivo 是可逆的。重复的海刺激带了白介素(IL ) 的 todown 规定 IL-10 的 -2, 和高水平。这研究证明两个 CD4~+and CD8~+ 告知海的 T 房间对海应答在 vivo，和第三注射重新质问被需要导致 T 房间的变应力缺乏。

英文摘要：

We have investigated the response of T cells to staphylococcal enterotoxin A （SEA） injections in vivo. We found that a single injection of SEA with an optimal dose of 10μg increased the expression of both CD4 and CD8 significantly. There was expansion of SEA-reactive T cells in vivo after SEA re-injection and the time interval between injections strongly influenced the responsiveness of CD4^＋ and CD8^＋ T cells. Anergy of T cells was observed after three SEA treatments. The time interval between injections mainly affected the unresponsiveness of CD4^＋ T cells, not CD8^＋ T cells. Marked deletion followed by anergy of CD4^＋ T cells was induced at short intervals, and anergy without obvious deletion of CD4^＋ T cells was induced at long intervals. We also found that the anergic state was reversible in vivo. Repeated SEA stimulation led to down-regulation of interleukin （IL）-2, and high levels of IL-10. This study showed that both CD4^＋ and CD8^＋ SEA-primed T cells were responsive to SEA rechallenge in vivo, and a third injection was needed to induce the anergy of T cells.