中文摘要：

对促性腺激素释放激素（GnRH）作用机制的研究是一个重要领域。文章综述了国内外GnRH的研究进展,认为GnRH与受体（Rs）结合后,要通过一系列的信号转导,调节和控制促卵泡激素（FSH）和黄体生成素（LH）的合成和分泌。Gn-RH受体后信号转导途径主要是通过3大信号转导系统完成的：环磷酸腺苷（cAMP）信号转导系统、蛋白激酶C（PKC）信号转导系统和丝裂原活化蛋白激酶（MAPK）信号转导系统。cAMP信号转导通路和PKC信号转导通路都属于G蛋白偶联的信号通路,二者最后都要通过激活MAPK信号转导系统来完成调控。这为进一步研究GnRH作用机制提供了依据,同时讨论了存在的问题,并对下一步的研究方向做出展望。

英文摘要：

It is an important area of research on the mechanism of gonadotropin-releasing hormone, The paper reviews the domestic and foreign advances on GnRH and think GnRH regulates the synthesis and secretion of FSH and LH after binding its receptor in a series of signal transduction. The GnRH post-receptor signal transduction pathway may consist of three major sig- nal transduction system： the cAMP signal transduction system, PKC signal transduction system and MAPK signal transduc- tion system, cAMP signal transduction pathway and PKC signal transduction pathway belong to G protein coupling signaling pathways, who both finish regulation by activating MAPK signal transduction system at last. It provides the base on the fur- ther study, some suggestions gived on existents problems and further research direction raised.