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食管癌放疗前后维医分型与T细胞亚群及NK细胞变化的关系
  • 期刊名称:新疆医科大学学报2012,35(1),15-19;
  • 时间:0
  • 分类:R735.1[医药卫生—肿瘤;医药卫生—临床医学]
  • 作者机构:[1]新疆医科大学附属肿瘤医院中西医科,乌鲁木齐830011, [2]新疆医科大学,乌鲁木齐830011
  • 相关基金:阁家自然科学基金(30860361)
  • 相关项目:食管癌放疗前后神经内分泌免疫改变与维医的相关研究
中文摘要:

目的探讨食管癌患者放射治疗前后维医分型与T细胞及NK细胞之间的关系。方法对放疗前后120例患者进行维医分型并用流式细胞仪检测T细胞及NK细胞水平。结果放疗前后维医分型构成比具有显著差异性,均以异常黑胆质为主;放疗后CD3、CD4与、CD4/CD8及NK细胞下降,CD8升高(P〈0.05);且放疗后变为异常黑胆质的患者T细胞及NK细胞变化有差异(P〈0.01);而放疗后变为非异常黒胆质的T细胞及NK细胞变化无统计学意义(P〉0.05)。结论异常黑胆质为放疗前后食管癌患者的主要维医分型;放疗后变为异常黑胆质的患者免疫功能受损更为严重。

英文摘要:

Abstract: Objective To explore the relation between Uyghur phocyte subsets and natural killer (NK) ceils of patients with Traditional esophageal Medieine Syndromes and T lyre carcinoma before and after radio therapy. Methods Before and after radiotherapy, 120 patients with esophageal cancer were divided accord ing to Uyghur traditional medicine theories. Flow cytometry (FCM) were applied to measure T lympho cyte subsets and NK cells. Results The proportion of Urgur Traditional Medieine Syndromes was significant difference before and after radiotherapy (P d0.01); After radiotherapy, the levels of CD3, CD4, CD4/CD8 NK cells were reduced, CD8 rose than beforeradiotherapy (P d0.05); The changes of Abnor mal Savda patients has significant difference (P d0.01), but nonabnormal Savda patients had no differ ence (P〉0.05). Conclusion ABnormal Savda is the major Uyghur Traditional Medieine Syndromes be fore and after undergoing radiotherapy; the immunologic function of Abnormal Savda patients were seri ously injuried after radiotherapy

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