中文摘要：

目的探讨放射治疗对新疆地区不同民族食管癌患者机体免疫功能的影响。方法分别收集放疗前和放疗后120例不同民族食管癌患者全血及血清;流式细胞术检测其T淋巴细胞及亚群、NK细胞,电化学发光法检测IL-6含量,ELISA法检测IL-1β和TNF-α含量;统计分析放疗前后不同民族之间各免疫指标的差异以及同一民族内部各指标的改变。结果治疗前,NK细胞在维吾尔族、汉族和哈萨克族患者之间差异无统计学意义,治疗后,IL-1β在维吾尔族、汉族和哈萨克族患者之间差异有统计学意义（P〈0.05）;在汉族患者中治疗前的总T细胞和IL-6均高于治疗后;在哈萨克族患者中治疗后的Th细胞和Th/Tc比值均低于治疗前,而治疗后的Tc细胞则高于治疗前（P〈0.05）。结论不同民族食管癌患者之间的的机体免疫功能存在差异,且放射治疗对不同民族患者免疫功能产生的影响不同,产生影响的途径也不同。

英文摘要：

Objective To explore the influence of immune function about radiation treatments for patients with esophageal cancer in Xinjiang different nationalities. Methods Whole blood and serum of 120 cases were respectively collected in esophageal patients before and after radiotherapy; T cells and, NK cells were detected by Flow Cytometry; the content of IL-6 was detected by electrochemical luminescence method;the content of II.-113 and TNF-c~ were detected; the differences of the immune index among different ethnic groups or in the same nation before and after radiation treatments were statistically analyzed. Results cells in the Uyghur patients were significant different between the Han nationality before treatment; NK thelevel of ILq~ was significant differences between Uyghurs and Han patients after treatment; before treat ment, total T cells and 1176 of Han nationality were higher than after treatment; In the Kazak patients, after treatment, the Th cells and Th/Tc ratio were lower and Tc cells were, higher than before treatment （P d0.05）. Conclusion The body＇s immune function exsit differences in different nationalities of esopha geal patients. And radiation treatments for patientsr immune function had different impact among three na tionalities, the impact also come from different path.