情志不畅与乳腺癌的发生、发展、预后密切相关。文章对古代医家及现代学者就肝郁与乳腺癌的发生、发展及辨病施治等方面进行了系统梳理,对情志因素与乳腺癌的关系进行分析,并从调控免疫抑制细胞的角度探讨了中医药干预的分子机制。作者认为,在乳腺癌的发生发展及治疗中,肝郁是基本病机,疏肝健脾是基本法则,调控免疫抑制是中药分子机制。
Depressive disorder is associated with the incidence of breast cancer development and prognosis. This paper sum-marizes the view of the ancient physicians and modern scholars on the occurrence of liver depression and breast cancer develop- ment and disease differentiation therapy to analyze the relationship between emotional factors and breast cancer and explore the molecular mechanisms of TCM intervention from the immunosuppressive cells point of view. Liver depression is the basic patho-genesis and the regulation of immune suppression is the molecular mechanism of Chinese medicine in the incidence of breast cancer development with method of soothing liver and strengthening spleen.