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中文摘要：
利用电喷雾串联质谱（ESI-MS^n）技术研究马钱苷的质谱碎裂机理，探讨其碎裂方式，并利用傅立叶变换离子回旋共振质谱（FTICR-MS）及SORI-CID高分辨率、高质量准确度对其碎裂机理进行验证研究。采用H／D交换和串联质谱的方法，发现马钱苷羟基上的活泼氢在质谱中性碎片丢失过程中较易被转移，表现出较大的化学活性。通过加入特定的Na^＋和Li^＋等碱金属离子，极大地提高了马钱苷化合物质谱分析的灵敏度，获得了更多的结构信息，建立了马钱苷化合物质谱鉴定和分析的新方法。
英文摘要：
Loganin was investigated systematically by electrospray ionization tandem mass spectrometry （ESI-MSn） to propose the logical fragmentation pathways. Product ion mass spectra examined at high mass resolution allowed unambiguous determination of the elemental composition of fragment ions by sustained off-resonance irradiation/collision-induced dissociation （SORI-CID） method in fourier transform ion cyclotron resonance mass spectrometry （FTICR-MS）. Through hydrogen and deuterium exchange, the fragment path of Loganin is further confirmed. Experiment demonstrates that [M＋Li]^＋ and [M＋Na]^＋ ions can provide complementary useful structural information for structure analysis of Loganin.
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