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幽门螺杆菌相关性慢性胃炎中医证候分类研究
  • ISSN号:1006-2157
  • 期刊名称:北京中医药大学学报
  • 时间:2014.3.30
  • 页码:156-159
  • 分类:R241[医药卫生—中医诊断学;医药卫生—中医临床基础;医药卫生—中医学]
  • 作者机构:[1]北京中医药大学东方医院北京100078, [2]北京中医药大学东直门医院, [3]北京怀柔中医院, [4]北京中医药大学医疗管理处
  • 相关基金:国家自然科学基金重大研究计划项目(No.91129714),国家自然科学基金项目(No.81270466)
  • 相关项目:ACAP4在非可控性炎症介质CCL18介导肿瘤细胞迁移及恶化的分子动力学机制研究
中文摘要:

目的对幽门螺杆菌(Hp)相关性慢性胃炎的证候、证候要素进行研究,探讨Hp感染的中医证候表达。方法收集非萎缩性胃炎和萎缩性胃炎各200例。应用因子分析和复杂系统熵聚堆2种统计方法对400例患者的四诊信息进行分析。结果Hp阳性慢性胃炎的病位要素有4个:肝、胃、脾、胆(结合临床和专家问卷调查将“胆”舍弃);而Hp阴性慢性胃炎的病位要素有3个:肝、胃、脾。Hp阴性和Hp阳性慢性胃炎的病性要素均为9个:气虚、阴虚、阳虚、气滞、湿、热、瘀血、食积、寒。共得出8个基本证型:类肝胃郁热证、类脾胃虚弱证、类湿热蕴结证、类饮食停滞证、类脾寒胃热证、类胃阴不足证、类肝胃不和证、类瘀阻胃络证。经∥检验,Hp阳性和Hp阴性慢性胃炎的病性要素分布无差异,但基本证型的分布有差异。经两两比较,结果表明Hp感染与证型分布明显相关(P〈0.01),以类胃阴不足证为最密切,其次是类脾胃虚弱证、类湿热蕴结证及类肝胃郁热证。结论Hp感染与湿、热相关,与阴虚关系更为密切。作为一种外来致病因素,Hp的邪气性质与湿、热密切相关,与热关系更大,且具有易伤阴液的特点。

英文摘要:

Objective To study the syndromes and syndrome factors of Helicobacter pylori (Hp)-related chronic gastritis, and discuss the expressions of TCM syndromes of Hp infection. Methods The patients with non-atrophic gastritis and atrophic gastritis (each n = 200) were chosen, and their data from TCM four examinations were analyzed by using factor analysis and entropy-reactor of complex system. Results There were 4 syndrome factors related to disease locations of Hp-positive chronic gastritis, including liver, stomach, spleen and gallbladder (gallbladder being given up after clinical and expert questionnaire), and there were 3 of Hp-negative chronic gastritis, including liver, stomach and spleen. There were 9 syndrome factors related to disease nature of Hp-positive or Hp-negative chronic gastritis, including qi deficiency, yin deficiency, yang deficiency, qi stagnation, phlegm, heat, blood stasis, food accumulation and cold. There were 8 basic syndrome types, including para-syndrome of depression-heat in liver and stomach, para-syndrome of spleen-stomach weakness, para-syndrome of damp-heat accumulation, para-syndrome of food stagnation, para-syndrome of spleen cold and stomach heat, para- syndrome of stomach yin deficiency, para-syndrome of liver qi invading stomach and para-syndrome of stasis in stomach collateral. After Chi-square test, the distribution of the syndrome factors related todisease nature had no difference between Hp-positive chronic gastritis and Hp-negative chronic gastritis, but that of basic syndrome types had difference. The results of pairwise comparison showed that Hp infection was significantly correlated to syndrome distribution ( P 〈 0.01 ), and it was most closely related to para-syndrome of stomach yin deficiency and followed by para-syndrome of spleen-stomach weakness, para-syndrome of damp-heat accumulatiorr and para-syndrome of depression-heat in liver and stomach. Conclusion Hp infection is correlated to dampness and heat, especially to yin deficiency. As a kind of exte

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期刊信息
  • 《北京中医药大学学报》
  • 中国科技核心期刊
  • 主管单位:中华人民共和国教育部
  • 主办单位:北京中医药大学
  • 主编:王永炎
  • 地址:北京市北三环东路11号
  • 邮编:100029
  • 邮箱:jbutcm@yahoo.com.cn
  • 电话:010-64287405
  • 国际标准刊号:ISSN:1006-2157
  • 国内统一刊号:ISSN:11-3574/R
  • 邮发代号:82-414
  • 获奖情况:
  • 1989年获全国高等医药学院校学报编辑质量优秀学报...,1990年获北京高等学校自然科学学报优秀编辑质量一等奖,1995年获北京市高校系统自然科学学报优秀学报一等奖,1995年获国家中医药管理局颁发的全国中医药优秀期...,1996年获中共中央宣传部、国家科学技术委员会、新...,2000年获国家中医药管理局颁发的全国中医药优秀期...,中国期刊方阵“双效”期刊
  • 国内外数据库收录:
  • 美国化学文摘(网络版),美国乌利希期刊指南,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊(2004版),中国北大核心期刊(2008版),中国北大核心期刊(2011版),中国北大核心期刊(2014版),中国北大核心期刊(2000版)
  • 被引量:32130