目的:探讨酒精性肝纤维化的中医临床证候分类,为临床证候规范化研究奠定基础。方法:对326例酒精性肝纤维化患者进行流行病学调查,应用因子分析、复杂系统熵聚堆方法分析中医证候分布特点。结果:酒精性肝纤维化中医临床证候常见肝郁脾虚、湿热蕴结、气滞血瘀、气阴两虚、肝肾阴虚、脾阳虚6个基本证型,临床涵盖率达90%以上。结论:通过建立该病的因子分析、复杂系统熵聚堆模型,揭示其中医证候特点,丰富了中医证候分类方法,有助于该病中医证候分类的客观化。
Objective: To study the classification of Chinese clinical syndrome differentiation of alcoholic liver fibrosis to establish foundation for the standardization of clinical syndrome research. Methods: 326 patients with alcoholic liver fibrosis were investigated. And factor analysis and entropy-reactor analysis of complex system were used to study the distribution of Chinese syndromes. Results: There were 6 basic syndromes including liver depression and spleen deficiency, accumulation of dampness and heat, Qi stagnation and blood stasis, defciency of both Qi and yin, yin eficiency of liver and kidney, and spleen Yang deficiency, which covered more than 90% of the clinical cases. Conclusion: The factor analytical model and entropy-reactor analytical model of syndrome distribution unveiled the Chinese syndrome characteristics of the disease, enriched methods of syndrome classification. It would promote syndrome classification towards the objective process of the disease.